[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 8, Issue 3 (6-2017) ::
Caspian J Intern Med 2017, 8(3): 178-182 Back to browse issues page
Diagnostic accuracy of fecal calprotectin in assessing the severity of inflammatory bowel disease: From laboratory to clinic
Soheila Moein , Durdi Qujeq *, Mostafa Vaghari Tabari , Mehrdad Kashifard , Karimollah Hajian
PhD Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran , d.qujeq@mubabol.ac.ir
Abstract:   (1152 Views)

Background: Inflammatory bowel disease (IBD) involves chronic inflammation of the digestive tract. In the past decades, fecal calprotectin has been proposed as a useful biomarker for the differential diagnosis between IBD patients and healthy controls. We designed this study to evaluate the diagnostic ability of fecal calprotectin (FC) and conventional inflammatory markers in IBD patients.

Methods: Thirty patients who underwent colonoscopy were cases and thirty healthy subjects undergoing colonoscopy as part of a medical check-up were the controls. These 2 groups were evaluated with regard to age and sex. Severity of the disease was evaluated based on disease endoscopic index. FC, Cross reactive protein (CRP) and Erythrocyte sedimentation rate (ESR) were measured using ELISA, colorimetric and Westergren methods, respectively. The obtained data were analyzed by independent test, correlation test and receiver operating characteristic (ROC) curve analysis. A p<0.05 was considered statistically significant.

Results: Fecal calprotectin level in the case group increased compared to control group (p<0.05).  Moreover FC has stronger correlation with disease endoscopic activity than conventional inflammatory markers (r=0.847 versus r= -0.44 for CRP and r=0.054 for ESR in Crohn's disease and r=0.798 versus r=0.463 for CRP and r=0.467 for ESR in ulcerative colitis). Receiver operating characteristic (ROC) curve analysis showed FC has larger area under the curve (AUC) than conventional inflammatory markers (1 versus 0.849 for CRP and 0.846 for ESR).

Conclusion: Discriminating IBD patients from healthy controls was better for FC than conventional inflammatory markers. Additionally, the results produced by FC correlate with the severity of IBD.

Keywords: Calprotectin, Inflammatory bowel disease, Marker, Severity
Full-Text [PDF 263 kb]   (349 Downloads)    
Type of Study: Original Article | Subject: Gastroentrology
Received: 2016/04/10 | Accepted: 2017/01/4 | Published: 2017/06/24
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >



DOI: 10.22088/cjim.8.3.178


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moein S, Qujeq D, Vaghari Tabari M, Kashifard M, Hajian K. Diagnostic accuracy of fecal calprotectin in assessing the severity of inflammatory bowel disease: From laboratory to clinic . Caspian J Intern Med. 2017; 8 (3) :178-182
URL: http://caspjim.com/article-1-743-en.html
Volume 8, Issue 3 (6-2017) Back to browse issues page
Caspian Journal of Internal Medicine
Persian site map - English site map - Created in 0.048 seconds with 800 queries by yektaweb 3535