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:: Volume 9, Issue 1 (1-2018) ::
Caspian J Intern Med 2018, 9(1): 54-59 Back to browse issues page
Relationship between β-Thalassemia minor and Helicobacter pylori infection
Mohammad Zamani , Amin Vahedi , Ahmad Tamaddoni , Ali Bijani , Mojgan Bagherzade , Javad Shokri-Shirvani
Department of Internal Medicine, Rohani Hospital, Babol University of Medical Sciences, Babol, Iran , javadshokry@gmail.com
Abstract:   (7481 Views)

Background: Until now, no study has been reported investigating the association between β-thalassemia minor and Helicobacter pylori (H. pylori) infection. This study was designed to compare H. pylori infection rate between β-thalassemia minor patients and healthy controls.
Methods: A number of 100 β-thalassemia minor patients (50 males, 50 females) and 100 gender-matched healthy controls were prospectively recruited in this study in a period of 3 months. The study population consisted of the people who referred to a health center in Babol, North of Iran, for premarital counseling. H. pylori status was assessed by measuring the anti-H. pylori IgG antibodies using enzyme-linked immunosorbent assay. Demographic information and informed consent were collected from all participants.
Results: The overall H. pylori infection rate was 43%. The infection was significantly more prevalent in thalassemia patients (53%) than in the controls (33%) in both univariate (OR=2.29, 95% CI: 1.3-4.06) and multivariable analyses (OR=2.05, 95% CI: 1.12-3.76). Age was the only significant factor which was positively correlated with the infection in β-thalassemia minor cases (OR=1.11, 95% CI: 1.02-1.2). Gender, blood groups, residency, and education level were not related to the infection.
Conclusions: According to the results, it can be concluded that β-thalassemia minor patients are possibly more susceptible to H. pylori infection than healthy people. Further studies are needed to discover more about the exact mechanisms of increased susceptibility to H. pylori infection in β-thalassemia minor patients

Keywords: Helicobacter pylori, thalassemia minor, prevalence
Full-Text [PDF 433 kb]   (1526 Downloads)    
Type of Study: Original Article | Subject: Internal
Received: 2017/05/12 | Accepted: 2017/06/13 | Published: 2017/10/18
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Zamani M, Vahedi A, Tamaddoni A, Bijani A, Bagherzade M, Shokri-Shirvani J. Relationship between β-Thalassemia minor and Helicobacter pylori infection. Caspian J Intern Med 2018; 9 (1) :54-59
URL: http://caspjim.com/article-1-1061-en.html


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Volume 9, Issue 1 (1-2018) Back to browse issues page
Caspian Journal of Internal Medicine
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