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:: دوره 12، شماره 4 - ( 6-1400 ) ::
جلد 12 شماره 4 صفحات 543-539 برگشت به فهرست نسخه ها
Efficacy and safety of Intranasal Ketamine and Midazolam for sedation of young pediatric patients; a double-blind, randomized clinical trial
چکیده:   (803 مشاهده)
Background: Pediatric patients feel significant fear and anxiety when undergoing surgeries. The ideal drug and its administration route have not been found yet. The aim of this study was to compare the efficacy and safety of intranasal (IN) ketamine and midazolam as premedication in children.
Methods: We studied 71 eligible pediatric patients undergoing elective urologic surgeries, aged 2 to 6 years. The degree of sedation and separation scores was compared between the two groups. Additionally, hemodynamic parameters, before premedication, after induction of anesthesia, and during surgery were documented and compared between two groups. Postoperatively, any side effect was recorded as well.
Results: Finally, the data from 71 children were analyzed.  Recovery time was significantly longer in group K (ketamine) compared to group M (midazolam); 27.86±4.42 vs 38.19± 6.67 minutes respectively (P=0.01). No significant difference was observed in terms of sedation score between two groups of K & M; 3.29±0.78 vs 3 ±0.71 respectively (P=0.17), and not regarding separation score; 2.51±0.61 & 2.31 ±0.52 respectively (P=0.01). Vital signs were kept within the physiological limits in both groups with no marked fluctuations.
Conclusion: To produce sedation in young children, both midazolam and ketamine were effective and safe by IN route.
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نوع مطالعه: Original Article | موضوع مقاله: Anesthesiology
دریافت: 1399/6/18 | پذیرش: 1399/10/6 | انتشار: 1400/6/28
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Khoshrang H, Emir Alavi C, Rimaz S, Mirmansouri A, Farzi F, Biazar G, et al . Efficacy and safety of Intranasal Ketamine and Midazolam for sedation of young pediatric patients; a double-blind, randomized clinical trial. Caspian J Intern Med. 2021; 12 (4) :539-543
URL: http://caspjim.com/article-1-2490-fa.html

Efficacy and safety of Intranasal Ketamine and Midazolam for sedation of young pediatric patients; a double-blind, randomized clinical trial. 1. 1400; 12 (4) :543-539

URL: http://caspjim.com/article-1-2490-fa.html



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دوره 12، شماره 4 - ( 6-1400 ) برگشت به فهرست نسخه ها
Caspian Journal of Internal Medicine
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