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Recover burn ointment for managing acute radiodermatitis in patients with breast cancer: A double blind randomized controlled trial
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چکیده: (2611 مشاهده) |
Background: Radiodermatitis is the most common complication of radiotherapy. There is no gold standard for managing the radiodermatitis. This study aimed to evaluate the effect of topical Recove® burn ointment; basically compounded of sesame oil, camphor, and zinc oxide; in preventing acute radiodermatitis.
Methods: This double blind RCT (IRCT No.: 201204047136N2) was performed on 71 patients that referred for radiotherapy after mastectomy to Shahid Rajaee Hospital (Babolsar-Iran) during 2013-2017. Patients were allocated into 2 groups; 34 in control group and 37 in Recove® group. Patients applied the ointment 2 times a day, before every radiation therapy session for 5 weeks. The radiation oncologist assessed the severity of dermatitis weekly for 5 weeks and graded it from 0 to 4 according to the RTOG criteria.
Results:Baseline characteristics including age, and BMI had no significant difference between groups. The Recover group patients experienced significantly less severe dermatitis compared to the controls (p<0.001). None of the patients in Recove® group encountered more than grade 2 of RTOG criteria, however, in the control group, 4 (12.9%)patients experienced grade 3 of RTOG and 3 (9.7%)patients developed grade 4 of RTOG at the end of the 5th week.
Conclusion: Our results indicate that Recove® ointment significantly reduces the severity of acute radiodermatitis. |
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متن کامل [PDF 207 kb]
(572 دریافت)
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نوع مطالعه: Original Article |
موضوع مقاله:
Oncology
دریافت: 1399/8/8 | پذیرش: 1400/5/31 | انتشار: 1400/12/2
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