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Can cytokines response play a role in the treatment of fatal leptospirosis?
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Ahmad Alikhani    , Kimia Mahmoodi , Leila Delavaryan , Ebrahim Salehifar , Ali Reza Rafiei , Mahmoud Sadeghi Zavare |
| Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol , drm_sadeghihz@yahoo.com |
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Abstract: (2383 Views) |
Background: The northern coastal regions of Iran are endemic for leptospirosis which may range from a subclinical illness to a progressively fatal disease. There has been growing evidence that inflammatory markers play a significant role in the severity and prognosis of leptospirosis. This study aimed to investigate inflammatory cytokines in patients with leptospirosis.
Methods: This descriptive-analytical prospective study was performed in 75 patients over 18 years old who had a positive microscopic agglutination test (MAT) titer from January to June 2019. SPSS software Version 20 was used for statistical analysis and the significance level was considered as p<0.05.
Results: The patients’ age enrolled in this study are from 21 to 75 years with a mean and standard deviation of 48.6 ± 14.0. The male to female ratio in our participants was 54/21. Fever was the most common symptoms in 66 (88.0%) patients, followed by myalgia in 62 (82.7%) cases. The level of interleukin 10 was significantly higher in severe illness (P=0.003) and fatal cases (p<0.028) compared with recovered patients. The level of TNF-α level was also higher in the severe illness and Weil's syndrome compared with the mild kind (P=0.022).
Conclusion: Our results showed that the levels of TNF-α and IL-10 significantly increased in severe leptospirosis. Also, IL-10 was significantly higher in fatal cases. The inhibition of IL-10 production might play an important role in decreasing the risk of fatal outcomes in leptospirosis. |
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| Keywords: Leptospirosis, Inflammatory cytokine, treatment, outcome, IL10 |
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Full-Text [PDF 192 kb]
(689 Downloads)
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Type of Study: Original Article |
Subject:
Infectious Diseases
Received: 2021/01/14 | Accepted: 2021/09/22 | Published: 2022/02/21
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