:: Volume 7, Issue 4 (10-2016) ::
Caspian J Intern Med 2016, 7(4): 283-289 Back to browse issues page
Both immune hormone IL-10 and parathormone tend to increase in serum of old osteoporotic people independently of 1, 25 dihydroxy vitamin D3
Mohamad Teimorian, Zeinab Jafarian, Seyed-Reza Hosseyni, Mahsa Rahmani, Mojgan Bagherzadeh, Azin Aghmajidi, Ali Bijani, Hajighorban Nooreddini, Amrollah Mostafazadeh *
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. , amrolah65@yahoo.com
Abstract:   (7814 Views)

Background: In this study, we determined the serum levels of IL-17A and IL-10 in context with 1, 2 dihydroxy vitamin D3, parathormone and Ca2+/Pi ions to investigate their pathological or protective roles respectively in bone metabolism.

Methods: The bone mineral density (BMD) was determined for 1203 participants using energy X-ray absorptiometry. Subjects with a history of diseases and using bone metabolism medications were excluded and finally serum IL-10 was measured in 82 osteoporotic and 74 healthy individuals (mean age ±SD of 71.04±6.9 and 68.58±6.9 respectively). Also, the serum level of IL-17A was assessed in 42 osteoporotic and 39 non-osteoporotic subjects (mean age±SD of 69.40±6.7 and 70.77±7.1, respectively). Serum levels of 1, 25-dihydroxyvitamin D3, Ca2+/Pi ions and parathormone were extracted from AHAP cohort data bank.

Results: IL-17A was detectable in 7.42(16.67%) osteoporotic subjects and 3.39(7.69%) normal subjects. Surprisingly, patient subjects exhibited a higher level of serum IL-10 than normal subjects (P=0.023). We found that the serum parathormone levels tend to increase in patient group (P=0.003) in comparison to normal control with no correlation with Il-10 levels. There was no significant difference between the two groups in the serum levels of 1, 25-dihydroxyvitamin D3, Ca2+and Pi ions.

Conclusion: In reaction to chronic inflammation old osteoporotic patients independent of 1, 25 dihydroxy vitamin D3 may produce a higher level of IL-10 to dampen production of inflammatory cytokines including IL-17A which in turn leads to speeding up parathormone production ultimately reaching a new homeostasis status in bone metabolism with normal serum Ca2+ /Pi ions.

Keywords: Osteoporosis, IL-10, IL-17A, Parathormone, 1, 25dihydroxy vitamin D3, Elderly
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Type of Study: Original Article | Subject: Imonology
Received: 2015/07/15 | Accepted: 2016/09/17 | Published: 2016/09/26


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Volume 7, Issue 4 (10-2016) Back to browse issues page