TY - JOUR JF - babol-caspjim JO - Caspian J Intern Med VL - 13 IS - 0 PY - 2022 Y1 - 2022/1/01 TI - Altered Serum and Cerebrospinal Fluid TNF-α, Caspase 3, and IL 1β in COVID-19 Disease TT - N2 - Background: We evaluated the levels of the tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and caspase-3 in the cerebrospinal fluid (CSF) and serum of COVID-19 patients to improve our knowledge about underlying mechanisms caused by this virus in central nervous system involvement. Case Presentation: This case series study included six COVID-19 patients from March 26, 2020, to April 17, 2020, and six healthy control patients. CSF and serum levels of TNF-α, IL-1β, and caspase-3 have been assayed using monoclonal antibodies-based ELISAs. Patients with COVID-19 had significantly higher level of IL-1β, TNF-α, and caspase-3 in serum (239.16±35.73 pg/ml, 100.50±12.49 pg/ml, 3.58±0.11pg/ml, p < 0.001) and CSF (146.66±17.55 pg/ml, 63.16±14.68 pg/ml,3.22±0.03pg/ml, p<0.001), respectively as compared to control. In addition, our results showed that these biomarkers were significantly higher in serum compared with CSF of the COVID-19 patients (p<0.001). Conclusion: This study provides essential information for understanding the pathogenesis of COVID-19 infection and sheds light on the potential mechanisms of virus transmission. The obtained data could be useful for designing new prevention and treatment strategies for COVID-19. SP - 264 EP - 269 AU - Ramezani, Mahtab AU - Rezaei, Omidvar AU - Alavi Darzam, Ilad AU - Hajiesmaeili, Mohammadreza AU - Amirdosara, Mahdi AU - Simani, Leila AU - Aliaghaei, Abbas AD - Department of Infectious Diseases, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran KW - Apoptosis KW - Inflammation KW - COVID-19 UR - http://caspjim.com/article-1-2510-en.html DO - 10.22088/cjim.13.0.264 ER -