AU - Mousavi Seresht, Leila AU - Farazestanian, Marjaneh AU - Yousefi, Zohreh TI - Comparison between single-agent chemotherapy in low-risk gestational trophoblastic neoplasia PT - JOURNAL ARTICLE TA - babol-caspjim JN - babol-caspjim VO - 14 VI - 1 IP - 1 4099 - http://caspjim.com/article-1-3287-en.html 4100 - http://caspjim.com/article-1-3287-en.pdf SO - babol-caspjim 1 ABĀ  - Background: Low-risk gestational trophoblastic neoplasia could be cured in the case of appropriate management with single-agent chemotherapy. This study was carried out to compare the efficacy of single-dose methotrexate versus Actinomycin-D in low-risk gestational trophoblastic neoplasia to analyze the most effective agent. Methods: This retrospective cohort study was conducted on the medical record of 170 cases with the diagnosis of low-risk gestational trophoblastic neoplasia from 2012 to 2019 to evaluate the response rate of single-dose weekly-methotrexate versus biweekly-Actinomycin-D. Results: Single agent chemotherapy was required in 170 patients with final risk score of less than 7. Among the 100 cases under weekly-methotrexate therapy, 29 patients were required second-line chemotherapy with Actinomycin-D and combination therapy which means complete remission of 71% with methotrexate, in comparison with 78.5% in the other group. Resistance was mostly seen in patients with documented choriocarcinoma in histology who had not received timely diagnosis and treatment. Conclusion: Individualized decision in the management of low-risk gestational trophoblastic neoplasia cases, based on histology, HCG, and history is the corn stone in successful treatment. CP - IRAN IN - LG - eng PB - babol-caspjim PG - 108 PT - Original Article YR - 2023