AU - Rezai, Mohammad-sadegh AU - Pourmousa, Rostam AU - Dadashzadeh, Roksana AU - Ahangarkani, Fatemeh TI - Multidrug resistance pattern of bacterial agents isolated from patient with chronic sinusitis PT - JOURNAL ARTICLE TA - babol-caspjim JN - babol-caspjim VO - 7 VI - 2 IP - 2 4099 - http://caspjim.com/article-1-575-en.html 4100 - http://caspjim.com/article-1-575-en.pdf SO - babol-caspjim 2 ABĀ  - Background: Treatment of chronic sinusitis is complicated due to increase of antibiotic-resistant bacteria. The aim of this study was to determine the multidrug resistance (MDR) pattern of the bacteria causing chronic sinusitis in north of Iran. Methods: This cross-sectional study was carried out on patients with chronic sinusitis. Bacterial susceptibility to antimicrobial agents was determined according to the CLSI 2013 standards. Double-disk synergy (DDS) test was performed for the detection of extended-spectrum beta-lactamase (ESBL) producing bacteria; also methicillin-resistant Staphylococcus (MRSA) strains were identified by MRSA screen agar. The MDR isolates were defined as resistant to 3 or more antibiotics. Data were analyzed using SPSS 17 software. Descriptive statistics was used to describe the features of the data in this study. Results: The rate of ESBL-producing bacteria was 28.75-37.03% among enterobacteriaceae and the rate of MRSA was 42.75%-60% among Staphylococcus strains. The most detectable rate of the MDR bacterial isolates was Gram-negative bacteria 39 (76.47%) and Enterobacter spp. 19(70.37%) was the most multidrug resistant isolate among Gram negative bacteria. Also 36 (73.46%) of the gram positive bacterial isolated were multidrug resistance and Staphylococcus aureus 9(90%) was the most MDR among Gram positive bacteria. Conclusion: Antimicrobial resistance is increasing in chronic bacterial sinusitis. The emergence of MRSA and ESBL bacteria causing chronic sinusitis is increasing CP - IRAN IN - Mazandaran Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran. LG - eng PB - babol-caspjim PG - 114 PT - Original Article YR - 2016