RT - Journal Article T1 - Central nervous system relapse prophylaxis in acute lymphoblastic leukemia (ALL) intrathecal chemotherapy with and without cranial irradiation JF - babol-caspjim YR - 2010 JO - babol-caspjim VO - 1 IS - 1 UR - http://caspjim.com/article-1-67-en.html SP - 27 EP - 30 K1 - Acute Lymphoblastic Leukemia (ALL) K1 - CNS relapse K1 - CNS relapse Prophylaxis K1 - Cranial irradiation K1 - Iintrathecal chemotherapy AB - Background: Central Nervous System (CNS) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, Intrathecal chemotherapy and cranial irradiation. The purpose of this study was to compare the effectiveness of intrathecal (IT) CNS chemotherapy alone versus combination of IT chemotherapy with cranial irradiation for prevention of CNS relapse.Methods: From 1998 to 2008 ninety eight cases of acute lymphoblastic leukemia (ALL) admitted in Amirkola Children Hospital were enrolled in this study. The chemotherapy regimen was on the basis of protocol of BFM-79. CNS prophylaxis consisted of intrathecal Cytarabin or Methotrexate, in addition to cranial irradiation for patients more than 3 years old. We assessed the incidence of CNC relapses over 10 years of CNS prophylaxis regimen. Results: From ninety eight cases, 53 were females and 45 were males. Twenty six were below 3 years old and seventy two were above 3 years old (p LA eng UL http://caspjim.com/article-1-67-en.html M3 ER -