TY - JOUR JF - babol-caspjim JO - Caspian J Intern Med VL - 10 IS - 4 PY - 2019 Y1 - 2019/9/01 TI - Bradycardia Caused by interaction of Venlafaxine and Cyclosporine: A case report TT - N2 - Background: Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are prescribed widely for the treatment of depression, anxiety disorders and other psychiatric disorders. Although antidepressants are considered as a safety drug category but unexpected cardiovascular events have been reported as the most serious complications. The aim of this study was to introduce a case presentation on bradycardia due to the drug interference of venlafaxine and cyclosporine. Case presentation: The patient was a 38-year old woman diagnosed with systemic lupus erythematosus 5 years ago, who was admitted to a general educational hospital in northern Iran due to intensified rheumatologic symptoms and complaining about abdominal pain. Cyclosporine tab were administered to the patient, 50 mg twice daily. Two weeks after the administration of cyclosporine, the level of blood cyclosporine was checked. The patient became bradycardic after starting a single dose of venlafaxine (heart rate 52 ppm). Cardiac assessment showed no reason for bradycardia and it subsided after a drop of venlafaxine. Conclusion: As a result of the potential adverse drug interactions between cyclosporine and antidepressants such as venlafaxine, physicians should be aware of the possibility of bradycardia in the simultaneous prescription of these drugs in cases. SP - 463 EP - 467 AU - Azizi, Marzieh AU - Elyasi, Forouzan AU - Niksolat Roodposhti, fatemeh AD - Department of Psychiatry, Psychiatry and Behavioral Sciences Research Center and addiction Institute, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran KW - Bradycardia KW - Venlafaxine KW - Cyclosporine KW - Serotonin-Norepinephrine reuptake inhibitors KW - Selective serotonin reuptake inhibitors. UR - http://caspjim.com/article-1-1321-en.html DO - 10.22088/cjim.10.4.463 ER -