en Anesthesiology Anesthesiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background:</em></strong> </span>Pain and shivering are two unpleasant problems in postoperative&nbsp;period. Various techniques are used to alleviate the postoperative shivering and pain.&nbsp; We compared the preemptive prescription of a single dose of intravenous meperidine and ketorolac on postoperative pain and shivering in patients undergoing cesarean section with spinal anesthesia.<br> <span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em></span> One hundred and fifty patients who were scheduled for elective cesarean section under spinal anesthesia were randomly allocated to one of three study groups to receive either intravenous ketorolac (group K), meperidine (group M) or normal saline (group P). Time to first analgesic request, analgesic requirement in the first 24 hours after surgery, body tympanic temperature, hemodynamic variables and incidence of shivering were assessed as outcome variables.<br> <span style="color:#0000FF;"><strong><em>Results:</em></strong> </span>There was no significant difference between meperidine and ketorolac groups in terms of prevalence of shivering, although both groups were different from the placebo group (p<0.04). The mean time to first analgesic request was longer in group k (3.8&plusmn;1.4) and groups M (3.3&plusmn;1.2) than in group P (2.1&plusmn;0.8) hours (p<0.001).<br> <span style="color:#0000FF;"><strong><em>Conclusions:</em></strong> </span>The preemptive prescription of a single dose of intravenous meperidine and ketorolac can provide a satisfying analgesia immediately after surgery and decrease shivering prevalence&nbsp;without any serious side effects.</span></span><br> <p></p><p></p> shivering, ketorolac, meperidine, spinal anesthesia, cesarean section 151 157 http://caspjim.com/browse.php?a_code=A-10-754-1&slc_lang=en&sid=1 Marzieh Beigom Khezri mkhezri88@gmail. 100319475328460011954 100319475328460011954 Yes Department of Anesthesiology , Faculty of Medicine, Qazvin University of Medical Sciences,Qazvin, Iran Maryam Al-sadat Mosallaei m.mosallaei93@gmail.com 100319475328460011955 100319475328460011955 No Department of Anesthesiology , Faculty of Medicine, Qazvin University of Medical Sciences,Qazvin, Iran Mahdi Ebtehaj mhdebtehaj@yahoo.com 100319475328460011956 100319475328460011956 No Department of Anesthesiology , Faculty of Medicine, Qazvin University of Medical Sciences,Qazvin, Iran Navid Mohammadi nvmohammadi2017@gmail.com 100319475328460011957 100319475328460011957 No Preventive Medicine and Public Health Research Center, Iran University of Medical Sciences, Tehran, Iran