Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1396
10
1
gregorian
2018
1
1
9
2
online
1
fulltext
en
Cryptosporidium spp. infection in Iranian children and immunosuppressive patients: A systematic review and meta-analysis
Infectious Diseases
Infectious Diseases
Review Article
Review Article
<span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background:</em></strong></span> Cryptosporidiosis is an important cause of diarrhea in children and immunosuppressive patients. The current study was intended to evaluate the prevalence rate of<em> Cryptosporidium</em> infection and clarify the epidemiological characteristics of the infection in both children and immunosuppressive patients in Iran.<br>
<span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em></span> Five English electronic databases including PubMed, Google Scholar, Science Direct, Scopus and Cochrane, and two Persian language databases Magiran and Scientific Information Database were searched. Additionally, reports from the Iranian congresses of parasitology and graduate student thesis dissertations were assessed manually.<br>
<span style="color:#0000FF;"><strong><em>Results:</em></strong></span> Out of 1856 studies from the literature search, our search resulted in a total of 27 articles published from 1991 to 2016. These include 14 reports on cryptosporidiosis in children and 13 papers regarding immunosuppressive patients. 8520 children and 2015 immunosuppressed cases were evaluated. Oocysts of <em>Cryptosporidium</em> were found in 3.8% and 8% children cases and immunosuppressed patients, respectively. There was a relatively high variation in the prevalence estimates among different studies, and the Q statistics was high among articles regarding children (p<0.0001) and also between records regarding immunosuppressed patients (p<0.0001). Findings showed that the prevalence rates of <em>Cryptosporidium</em> infection are significantly higher in children under 5 years (P=0.00).<br>
<span style="color:#0000FF;"><strong><em>Conclusions:</em></strong></span> In summary, the present study provides a comprehensive view of the epidemiology of <em>Cryptosporidium</em> in children and immunosuppressive patients in Iran. Furthermore, a multidisciplinary and multicenter study to evaluate the real prevalence of <em>Cryptosporidium</em> infection and to determine its risk factors using an adequate sample size and standardized methods is highly recommended.</span></span><br>
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Children, Cryptosporidium spp., Cryptosporidiosis, Immunosuppressive patients, Iran, Prevalence
106
115
http://caspjim.com/browse.php?a_code=A-10-675-2&slc_lang=en&sid=1
Narges
Kalantari
n.kalantari@mubabol.ac.ir
100319475328460011895
100319475328460011895
No
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Salman
Ghaffari
s.ghaffari@mubabol.ac.ir
100319475328460011896
100319475328460011896
Yes
Department of Parasitology and Mycology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Masomeh
Bayani
m_bayani@yahoo.com
100319475328460011897
100319475328460011897
No
Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran