en Oncology Oncology case report case report <p style="line-height: 115%; text-indent: 0cm; margin-top: 0cm; margin-right: 0cm; margin-bottom: 0pt;"><span style="font-size: 14px;"><span style="font-family: times new roman;"><b><i><span style="color: blue; line-height: 115%;">Background:</span></i></b><b><span style="line-height: 115%;"><font color="#000000"> </font></span></b><span style="line-height: 115%;"><font color="#000000">Melanoma is a neoplasm derived commonly from melanocytic cells of skin. Although coetaneous presentation of malignant melanoma is easily recognizable, the presentation of melanoma in other organs is so confusing. In particular, when it metastasizes to other organs, many bizarre figures and unusual organs may be involved. In this report, we present a case of </font><span style="color: black;">primary duodenal malignant melanoma.</span></span></span></span></p> <p style="line-height: 115%; text-indent: 0cm; margin-top: 0cm; margin-right: 0cm; margin-bottom: 0pt;"><span style="font-size: 14px;"><span style="font-family: times new roman;"><b><i><span style="color: blue; line-height: 115%;">Case Presentation</span></i></b><i><span style="color: blue; line-height: 115%;">:</span></i><span style="line-height: 115%;"><font color="#000000"> A 68-year-old man presented with a history of </font><span style="color: black;">iron deficiency anemia</span><font color="#000000">. </font><span style="color: black;">The upper gastrointestinal endoscopy showed a prominent papilla of duodenum along with an ulcerative lesion adjacent to second part of duodenum. Histopathologic evaluation showed a high-grade malignant neoplasm involving the bowel wall which was labeled for S100 protein and markers of melanocytic differentiation; Melan-A indicating the definitive diagnosis of malignant melanoma of</span><font color="#000000"> the second portion</font><span style="color: black;"> of duodenal mucosa.</span></span></span></span></p> <p style="line-height: 115%; text-indent: 0cm; margin-top: 0cm; margin-right: 0cm; margin-bottom: 0pt;"><span style="font-size: 14px;"><span style="font-family: times new roman;"><b><i><span style="background: white; color: blue; line-height: 115%;">Conclusions:</span></i></b><b><span style="background: white; line-height: 115%;"><font color="#000000"> </font></span></b><span style="line-height: 115%;"><font color="#000000">In patients with a history of </font><span style="color: black;">iron deficiency anemia</span><font color="#000000">, any GI symptom should be evaluated carefully. However, the diagnosis of primary GI melanomas in patients without any history of melanoma is possible. Full medical investigations are recommended in these patients with primary mucosal lesions.</font></span></span></span></p> Melanoma, Duodenum, Gastrointestinal tract 312 315 http://caspjim.com/browse.php?a_code=A-10-520-2&slc_lang=en&sid=1 Kazem Anvari Anvarik@mums.ac.ir 100319475328460013113 100319475328460013113 No Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Masoumeh Gharib Gharibm@mums.ac.ir 100319475328460013114 100319475328460013114 No Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Amir Hossein Jafarian Jafariana@mums.ac.ir 100319475328460013115 100319475328460013115 No . Birjand Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, Iran Amin Saburi aminsaburi@yahoo.com 100319475328460013116 100319475328460013116 No . Birjand Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, Iran Seyed Alireza Javadinia Javadiniaa941@mums.ac.ir 100319475328460013117 100319475328460013117 Yes Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran