en Neurology Neurology Short Communication Short Communication <span style="font-size: 14px;"><span style="font-family: times new roman;">Multiple sclerosis (MS) is an inflammatory demyelinating disease, which is considered as a common autoimmune disorder in young adults. A growing number of evidences indicated that the impairment in non-neural tissues plays a significant role in pathology of MS disease. There are bidirectional relationship, metabolic activities and functional similarity between central nervous system (CNS) and kidneys which suggest that kidney tissue may exert remarkable effects on some aspects of MS disorder and CNS impairment in these patients compels the kidney to respond to central inflammation. Recently, it has been well documented that hormonal secretion possesses the important role on CNS abnormalities. In this regard, due to the functional similarity and significant hormonal and non-hormonal relationship between CNS and kidneys, we hypothesized that kidneys exert significant effect on initiation, progression or amelioration of MS disease which might be regarded as potential therapeutic approach in the treatment of MS patients in the future.</span></span><br> <p></p> Multiple sclerosis, Kidneys, Central nervous system, Hormones 206 210 http://caspjim.com/browse.php?a_code=A-10-836-1&slc_lang=en&sid=1 Sahar Rostami srostami.m@gmail.com 100319475328460013166 100319475328460013166 No Department of Clinical Biochemistry, Faculty of Medicine, Tarbiat Modarres University, Tehran, Iran Mohammad Sajad Emami Aleagha s.imamiclinbio@gmail.com 100319475328460013167 100319475328460013167 No Department of Clinical Biochemistry, Faculty of Medicine, Tarbiat Modarres University, Tehran, Iran Maryam Ghasemi-Kasman maryam.ghasemi65@gmail.com 100319475328460013168 100319475328460013168 No Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Abdolamir Allameh allameha@modares.ac.ir 100319475328460013169 100319475328460013169 Yes Department of Clinical Biochemistry, Faculty of Medicine, Tarbiat Modarres University, Tehran, Iran