en Biochimestry Biochimestry Original Article Original Article <span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background:</em></strong></span> Breast cancer is the most common serious disease around the world. The trace elements have a vital role in the metabolism and chemotherapy may change the level of metal ions. Due to the ambiguity of the existence in this regard, the study examined the trace element serum levels in women with breast cancer before and after chemotherapy .<br> <span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em> </span>Sixty patients were studied undergoing specialist. First sampling was taken before chemotherapy (after 4 weeks of surgery) and second sampling was taken after the completion of 3 courses of chemotherapy, approximately 9 weeks after the first chemotherapy. The patients took Adriamycin 60mg/m²&nbsp;Cytoxan 600mg/m². Serum zinc and iron levels were measured using standard spectrophotometric method. Measurement of serum copper was done by atomic absorption spectroscopy<em>.</em><br> <span style="color:#0000FF;"><strong><em>Results:</em></strong></span> Serum zinc and iron levels in women after chemotherapy significantly decreased (p<0.001), however, the serum level of copper increased but was not significant (P=0.676).<br> <span style="color:#0000FF;"><strong><em>Conclusions:</em> </strong></span>Our findings demonstrate significant decrease in zinc and iron levels in breast cancer patients after 3 courses of Adriamycin and Cytoxan chemotherapy. Prescribing zinc supplements can be useful after chemotherapy</span></span><p></p> Breast cancer, Chemotherapy, Trace elements, Adriamycin, Cytoxan 134 139 http://caspjim.com/browse.php?a_code=A-10-71-4&slc_lang=en&sid=1 norjis ahmadi norjisahmay@gmail.com 100319475328460011924 100319475328460011924 No Department of Biochemistry, Faculty of Science, University of Payam Noor Tehran, Tehran Soleiman Mahjoub smahjoub20@gmail.com 100319475328460011925 100319475328460011925 Yes Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Reza Hajihosseini hosseini@pnu.ac.ir 100319475328460011926 100319475328460011926 No Department of Biochemistry, Faculty of Science, Payam Noor University, Tehran Mostafa Taherkhani thaherkhani7816@gmail.com 100319475328460011927 100319475328460011927 No Student Research Committee, School of Medicine, Babol University of Medical Sciences, Babol, Iran Dariush Moslemi moslemi_d@yahoo.com 100319475328460011928 100319475328460011928 No Department of Radiation Oncology, Babol University of Medical Sciences, Babol, Iran