en Obstetrics & Gynicology Obstetrics & Gynicology Original Article Original Article <span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background:</em></strong></span> Using oral glucose for glucose challenge test (GCT) and glucose tolerance test (GTT) is problematic, especially in early pregnancy when the pregnant woman is experiencing gastrointestinal complications. This research seeks to investigate the relationship between the ratio of Triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) and the risk of gestational diabetes and large for gestational age (LGA) fetus for suggesting a more appropriate index for diagnosis of gestational diabetes.<br> <span style="color:#0000FF;"><strong><em>Methods:</em></strong> </span>The present cross-sectional study investigated pregnant women visiting the Perinatal Clinic of Ayatollah Rouhani Hospital in Babol for prenatal care from September 2015-2016. The GCT was performed on these pregnant women at 24-28 weeks as a screening test and their lipid profile, including HDL-C and TG, was simultaneously assessed after eight to 14 hours of fasting.<br> <span style="color:#0000FF;"><strong><em>Results:</em></strong></span> Significant differences were observed between women with and without gestational diabetes in terms of mean triglyceride, HDL, LDL/HDL ratio, triglyceride/LDL ratio and triglyceride/HDL ratio. The cut-off point of TG/HDL in the GTT was 4.254 with a sensitivity of 79.07% and specificity of 78%.<br> <strong><em>Conclusions:</em></strong> According to the results obtained, lipid profile can help predict the risk of gestational diabetes, especially TG/HDL ratio that has a high sensitivity to diagnose gestational diabetes, while, lipid indices could not predict birth of a LGA neonate.<br> <span style="color:#0000FF;"><strong><em>Keywords</em></strong><em>:</em></span> Gestational Diabetes, Triglyceride, Cholesterol, Triglyceride/HDL Ratio, Risk&nbsp;</span> Gestational Diabetes, Triglyceride, Cholesterol, Triglyceride/HDL Ratio, Risk Factors 368 375 http://caspjim.com/browse.php?a_code=A-10-863-1&slc_lang=en&sid=1 Shahnaz Barat shahnaz_barat200@yahoo.com 100319475328460014050 100319475328460014050 No Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Zohreh Batebi rohanresearch88@gmail.com 100319475328460014051 100319475328460014051 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Zinatossadat Bouzari z_b412003@yahoo.com 100319475328460014052 100319475328460014052 Yes Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Azita Ghanbarpour dr_ghanbarpour@yahoo.com 100319475328460014053 100319475328460014053 No Infertility and Reproductive Health Research Center, Health Research Institute & Department of Obstetrics & Gynecology, Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.