en Hematology Hematology case report case report <span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background</em></strong><em>:</em></span> Neurofollicular hamartoma (NFH) is characterized histopathologically by fascicles of spindle cells that laterally delimited by hyperplastic folliculosebaceous units. It usually appears on face, near the nose or nasolabial fold. It does not manifest true neural differentiation and recently the term spindle cell predominant trichodiscoma (SCPT) has been used instead.<br> <span style="color:#0000FF;"><strong><em>Case Presentation:</em></strong> </span>We present a case of a 40-year-old male with co-incidence of NFH and basal cell carcinoma (BCC) that the mesenchymal components of NFH were similar to SCPT but these components highly expressed S-100 protein. We also discuss about the histological aspect of the neoplasia in this report and consider the findings of other reports in association with classification of NFH by means of cellular markers and morphological resemblance to other skin hamartomas.<br> <span style="color:#0000FF;"><strong><em>Conclusion:</em></strong> </span>Neurofollicular hamartoma is a rare benign tumor that thought to represent the cellular end of a morphological spectrum with trichodiscoma. The morphological features and expression of S100 protein in neural element helped us to achieve the diagnosis of neurofollicular hamartoma. However, variable reports of S-100 protein expression in NFH are available and further studies are needed to determine the classification of this tumor.&nbsp;</span></span> hypocalcemia, celiac disease, Enteropathy-associated T-cell lymphoma (EATL) 111 114 http://caspjim.com/browse.php?a_code=A-10-1005-1&slc_lang=en&sid=1 Maria Belen Alonso-Ortiz belalor@yahoo.es 100319475328460015200 100319475328460015200 No Department of Internal Medicine, Gran Canaria University Hospital, Las Palmas, Spain Noel Lorenzo Villalba noellorenzo@gmail.com 100319475328460015201 100319475328460015201 Yes Department of Internal Medicine, Chretien Hospital, Liege, Belgium Emilio Almaraz Marroquin eldocmilo@hotmail.com 100319475328460015202 100319475328460015202 No Department of Internal Medicine, Yeovil District Hospital, Yeovil, United Kingdom Melek Kechida kechida_mel_lek@hotmail.com 100319475328460015203 100319475328460015203 No Department of Internal Medicine. Bourguiba University Hospital Fattouma, Monastir, Tunisia Manuel Mendez Bailon manuel.mendez@salud.madrid.org 100319475328460015204 100319475328460015204 No Department of Internal Medicine, San Carlos University Hospital, Madrid, Spain Imanol Pulido Gonzalez tuamigoima@gmail.com 100319475328460015205 100319475328460015205 No Department of Internal Medicine, Gran Canaria University Hospital, Las Palmas, Spain