en Obstetrics & Gynicology Obstetrics & Gynicology Review Article Review Article <p><span style="font-size: 14px;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background:</em></strong></span> Cytomegalovirus (CMV) infection is one of the most common infectious diseases in pregnant women in terms of global impact and is related with many adverse health consequences during pregnancy. For the first time, we performed a systematic review and meta-analysis study to evaluate the possible association between CMV infection and preeclampsia (PE).<br> <span style="color: rgb(0, 0, 255);"><strong><em>Methods</em></strong><em>:</em> </span>A comprehensive literature search <strong>to </strong>identify the relevant papers published earlier than February 2018 was performed in PubMed, ISI (Web of Science), Google Scholar and SCOPUS databases. We followed the PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines for design, analysis and interpretation of results.&nbsp; Pooled odds ratio (OR) and 95% confidence intervals (CI) were estimated using a random-effects meta-analysis model. Heterogeneity was assessed with Q-test and <em>I²</em> statistic<strong>s</strong>.<br> <span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> A total of 13 studies including 6158 pregnant women (2734 women with PE and 3424 healthy controls) met the eligibility criteria. The results of meta-analyses based on PCR (OR: 3.09; 95% CI:0.72&ndash;13.24; I²=57.3%), IgG-ELISA (OR: 1.24; 95% CI:0.83&ndash;1.85; I²=71%) and IgM-ELISA (OR: 1.04; 95% CI:0.66&ndash;1.65; I²=0.0%) demonstrated that CMV infection could not be a potential risk factor for PE.<br> <span style="color: rgb(0, 0, 255);"><strong><em>Conclusions:</em></strong> </span>In conclusion, results of the present study demonstrated that CMV infection could not be a potential risk for developing PE. More epidemiological and experimental studies are needed to investigate the impact of CMV infection on the development of PE.</span></span><br> &nbsp;</p> Cytomegalovirus infection, Pregnant women, Preeclampsia 211 219 http://caspjim.com/browse.php?a_code=A-10-1065-2&slc_lang=en&sid=1 Zahra Geraili geraili.stat@gmail.com 100319475328460013127 100319475328460013127 No Department of Biostatistics and Epidemiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran Seyed Mohammad Riahi riahim61@gmail.com 100319475328460013128 100319475328460013128 No Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Soghra Khani khanisog343@gmail.com 100319475328460013129 100319475328460013129 No Sexual and Reproductive Health Research Center, Mazandaran University of Medical Sciences, Sari, Iran Masomeh Bayani m_baiany@yahoo.com 100319475328460013130 100319475328460013130 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Ali Rostami alirostami1984@gmail.com 100319475328460013131 100319475328460013131 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Karimollah Hajian-Tilaki drhajian@yahoo.com 100319475328460013132 100319475328460013132 No Department of Biostatistics and Epidemiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran Malihe Nourollahpour Shiadeh malihe.nurollahpur@gmail.com 100319475328460013133 100319475328460013133 Yes Sexual and Reproductive Health Research Center, Mazandaran University of Medical Sciences, Sari, Iran