en Oncology Oncology case report case report <span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background</em></strong><em>:</em></span> Cardiac metastasis of unclassified renal cell carcinoma (RCC) subtype is very rare, and even more so is an isolated right ventricular (RV) metastasis without vena cava extension or right atrial involvement. To the best of our knowledge, this is the first report of a cardiac metastasis of an unclassified RCC (an aggressive RCC) without vena cava extension.<br> <span style="color:#0000FF;"><strong><em>Case Presentation</em></strong><em>:</em></span> A 61-year-old African American male with past medical history of hypertension and schizophrenia presented to the emergency room following 2 episodes of syncope and 3-month history of progressive neck mass. CT scan of neck, abdomen and pelvis showed bulky left cervical, supraclavicular and axillary lymph node, mass in anterior aspect of heart, and multiple solid left renal masses and probable right renal mass. Echocardiogram revealed a large RV mass with deformation of the RV free wall suggesting malignant growth. Core biopsy of the right superficial gluteal mass revealed a metastatic poorly differentiated carcinoma of likely renal origin, with a possibility of an unclassified RCC. Due to the extent and burden of metastasis, patient and family members agreed to conservative management and evaluation for hospice care.<br> <span style="color:#0000FF;"><strong><em>Conclusion</em></strong><em>:</em></span> Cardiac metastasis of unclassified RCC is rare, and even more so is an isolated RV metastasis without vena cava extension or right atrial involvement, and the present case, to the best of knowledge is the first of such rare presentation.</span></span><br> &nbsp; Cardiac tumor, metastasis, right ventricular mass, unclassified renal cell carcinoma 235 238 http://caspjim.com/browse.php?a_code=A-10-1131-1&slc_lang=en&sid=1 Oluwaseun Akinseye oakinsey@uthsc.edu 100319475328460016866 100319475328460016866 No Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA Devarshi Ardeshna dardesh2@uthsc.edu 100319475328460016867 100319475328460016867 No Department of Medicine, University of Tennessee College of Medicine, Memphis, Tennessee, USA Meron Teshome mteshome@uthsc.edu 100319475328460016868 100319475328460016868 No Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA Shadwan Alsafwah salsafwa@uthsc.edu 100319475328460016869 100319475328460016869 Yes Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA