en Biochimestry Biochimestry Original Article Original Article <span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background</em></strong><em>:</em></span> C-reactive protein (CRP), creatine kinase-muscle (CK-MM) and aldolase A (AldoA) levels are predicted to be realistic biomarkers of osteoarthritic disorders (OADs). The objective of the study was to evaluate the levels of CRP, CK-MM, and AldoA and determine their correlations with risk factors such as inflammation, muscle degeneration, and skeletal muscle damage for OADs.<br> <span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em></span> Baseline data from 297 patients, average aged 60.17&plusmn;7.19 years, suffering with OADs for 5.75&plusmn;1.32 years and 315 participants, average aged 58.96&plusmn;8.63 years, without OADs were collected in this cross-sectional study. Separate analyses were performed for the participants with and without OAD symptoms confirming with X-ray or MRI. Blood CRP, CK-MM, and AldoA levels were estimated. The receiver operating characteristic (ROC) curves, their respective 95% confidence intervals (CIs), and significance values were compared between participants with and without OADs to identify the risk factors for OADs in relation to biomarkers.<br> <span style="color:#0000FF;"><strong><em>Results</em></strong><em>:</em></span> In patients with OADs, who exhibited degenerative changes on musculoskeletal joints and risk factors based on the elevated levels of CRP, CK-MM, and AldoA having their mean&plusmn;SD values, 7.22&plusmn;6.09 mg/L,135.2&plusmn;78.56 U/L and 8.09&plusmn;2.15 U/L, respectively. Their respective values of areas under the curves (AUC) of ROC curves were 0.76, 0.68 and 0.91 respectively, of which all exhibited highly significant differences (p<0.0001) compared with the control subjects.<br> <span style="color:#0000FF;"><strong><em>Conclusion</em></strong><em>:</em></span> It is concluded from the results that the elevated levels of studied biomarkers represent the predictive above-mentioned risk factors during OADs; therefore, monitoring CRP, CK-MM and AldoA levels may be an effective diagnostic method confirming with radiological imaging.</span></span> Osteoarthritic disorders, Diagnostic protocol, Biochemical markers, Risk factors, degenerative changes 25 35 http://caspjim.com/browse.php?a_code=A-10-1136-1&slc_lang=en&sid=1 Apurba Ganguly apurbaganguly15@gmail.com 100319475328460015027 100319475328460015027 Yes Founder and Chief Scientific Officer, OPTM (Organic Phyto Therapeutic Method) Research Institute, Kolkata, India