Caspian Journal of Internal Medicine

en Epidemiology and Outcomes of Candidemia in a Referral Center in Tehran Infectious Diseases Infectious Diseases Original Article Original Article <div>Background: Bloodstream infection with Candida, or candidemia, is the most common Candida systemic infection. In this study, we investigated the characteristics of patients with candidemia to provide appropriate perspectives on these patients and reduce the associated mortality and morbidity. Methods: In this cross-sectional study, all patients with at least one positive blood culture of Candida spp. were investigated from April 2015 to March 2016 in Imam Khomeini Hospital Complex, Tehran, Iran. Results: A total of 74 patients (44 men and 30 women), with the mean age of 53.15±17.89 years, were enrolled in this study. Non-albicans Candida species was responsible for candidemia in 67.6% (50.74). The mean therapy intervals were 7 and 5.6±1.5 days in patients who died and were discharged, respectively. The differences in frequencies of urinary catheter and mechanical ventilation were statistically significant among patients who died and survived (P<0.001). Among the discharged patients, antifungal therapy was administered to 30.8% (12.39). The mortality rate was 54.3% (19.35) in the medical ward, 5.7% (2.35) in the surgical ward, and 40% (14.35) in the intensive care unit (P=0.041). <a background-color:="" font-size:="" name="_Hlk503279499" new="" style="font-family: " times="">The treatment was significantly associated with lower mortality than those with no treatment </a>(OR=0.150 [0.023-0.996], P=0.05). Conclusion: The number of candidemia cases caused by non-albicans Candida species is continuously increasing in our center. We demonstrated the epidemiologic characteristics of patients with candidemia and the significant effects of timely and appropriate treatment on their outcomes. Further studies are needed to illuminate more aspects of this healthcare problem</div> Candidemia, Candida albicans, Mortality, Morbidity 73 79 http://caspjim.com/browse.php?a_code=A-10-1178-1&slc_lang=en&sid=1 Mohammadreza Salehi salehi.mohamad3@gmail.com 100319475328460015031 100319475328460015031 No Department of Infectious and Tropical Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Zahra Ghomi zgh1881@gmail.com 100319475328460015032 100319475328460015032 No School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Reza Mirshahi rezamirshahi@gmail.com 100319475328460015033 100319475328460015033 No Eye research center, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran Seyed Ali Dehghan Manshadi sealdema@yahoo.com 100319475328460015034 100319475328460015034 Yes Department of Infectious and Tropical Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Omid Rezahosseini omidrezahosseini@yahoo.com 100319475328460015035 100319475328460015035 No Department of Infectious and Tropical Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran