en Endocrinology Endocrinology Original Article Original Article <span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background</em></strong><em>:</em></span> Different benefits of various herbal medicines in decreasing blood sugar have been reported in different clinical trials so far. Considering the growing tendency toward these combinations and the booming market, inappropriate advice is growing accordingly. Hence, it is necessary to evaluate the effects and possible complications of such combinations on health status and blood glucose control.<br> <span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em></span> Two 38-subject groups were formed and a 12-week treatment program was administered for both groups. The inclusion criteria were failure to control blood glucose with two oral medicines, unwillingness to inject insulin. The medicine was prepared in capsules by Booali Company. Each capsule weighed 750 mg and contained nettle leaf 20% (w/w), berry leaf 10% (w/w), onion and garlic 20% (w/w), fenugreek seed 20% (w/w), walnut leaf 20% (w/w), and cinnamon bark 10% (w/w) all in powder.<br> <span style="color:#0000FF;"><strong><em>Results</em></strong><em>:</em></span> At the beginning of the study, there was no significant difference between the subjects regarding the evaluated parameters, but after the intervention, the level of glucose was significantly lower in fasting (P=0.0001) and 2-hour postprandial(P=0.002) levels. The level of glycated hemoglobin A1c (HbA1c) (P=0.0001) also decreased from 0.33&plusmn;9.72 % to 0.20&plusmn;8.39 %<span dir="RTL">.</span> Finally, the level of insulin resistance reduced from 1.9&plusmn;4.1 to 1.4&plusmn;2.6 (P=0.001) after consuming herbal medicine.<br> <span style="color:#0000FF;"><strong><em>Conclusion</em></strong><em>:</em></span> According to the results of the current study, the herbal combination was effective in controlling blood sugar, and considering the reduction of HbA1c by 1.31 %, it seems that the herbal combination is an effective medicine to treat diabetes.</span></span><br> &nbsp; Type 2 Diabetes, Herbal Medicine, Insulin-Resistance 12 20 http://caspjim.com/browse.php?a_code=A-10-38-11&slc_lang=en&sid=1 Mahmoud Parham mahmoud51dr@yahoo.com 100319475328460019884 100319475328460019884 No Gastroenterology & Hepatology Disease Research Center, Qom University of Medical Science, Qom, Iran Mohammad Bagherzadeh 100319475328460019885 100319475328460019885 No Clinical Research Development Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran Majid Asghari crdc@muq.ac.ir 100319475328460019886 100319475328460019886 No Department of Traditional Medicine, Qom University of Medical Sciences, Qom, Iran Hossein Akbari akbari1350@yahoo.com 100319475328460019887 100319475328460019887 No Department of Epidemiology, Kashan University of Medical Sciences, Kashan, Iran Zahra Hosseini zha2515@yahoo.com 100319475328460019888 100319475328460019888 No Department of Radiology Kashan University of Medical Sciences, Kashan, Iran Maryam Rafiee m.rafiee@yahoo.com 100319475328460019889 100319475328460019889 No Department of Obstetrics and Gynecology, Kashan University of Medical Sciences, Kashan, Iran Jamshid Vafaeimanesh jvafaeemanesh@yahoo.com 100319475328460019890 100319475328460019890 Yes Gastroenterology & Hepatology Disease Research Center, Qom University of Medical Science, Qom, Iran