en Internal Internal Original Article Original Article <span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background</em></strong><em>:</em></span> Given the fact that various studies have reported the positive effects of hydroxyethyl starch therapy in controlling shock, this study aimed to compare the effects of hydroxyethyl starch on modifying acidosis and treating patients with aluminum phosphide poisoning.<br> <span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em></span> This was a randomized clinical trial that was conducted on 60 patients with aluminum phosphide poisoning. We compared the two groups of patients treated with hydroxyethyl starch and normal saline. Base excess and serum pH of arterial blood gases (ABG) were measured before and after the treatment and compared by t-test.<br> <span style="color:#0000FF;"><strong><em>Results</em></strong><em>:</em> </span>Results showed that arterial pH in the starch group and normal saline group increased by 0.13 and 0.18, respectively, and the difference between the two groups was not statistically significant. The difference in the base excess before and after treatment in the starch group and normal saline group was 6.41 and 5.39, respectively, and the difference between the two groups was not statistically significant. Changes in mean values of arterial pH after the intervention in comparison with before treatment were statistically significant (p<0.05).<br> <span style="color:#0000FF;"><strong><em>Conclusion</em></strong><em>:</em></span> Overall, the results of the present study show that starch is at least as effective as normal saline in treating acidosis in patients poisoned with aluminum phosphide and can be used instead of normal saline, and both of the two&nbsp;treatments&nbsp;could be equally effective.</span> Hydroxyethyl Starch, Aluminum Phosphide, Rice tablet 271 275 http://caspjim.com/browse.php?a_code=A-10-1177-1&slc_lang=en&sid=1 Gholamabbas Kafi 1gholamabbaskafi@gmail.com 100319475328460018047 100319475328460018047 No Forensic medicine and toxicology, Tehran University of Medical Sciences, Tehran, Iran Samaneh Akbarpour 2samaneakbarpoor@gmail.com 100319475328460018048 100319475328460018048 No Occupational Sleep Research Center (OSRC), Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran Mohammad Arefi 3mohammadarefi@gmail.com 100319475328460018049 100319475328460018049 Yes Baharloo Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Behnam Behnoush 4BehnamBehnoush@gmail.com 100319475328460018050 100319475328460018050 No Forensic medicine and toxicology, Tehran University of Medical Sciences, Tehran, I.R. Iran. Mahin Ahmadi Pishkuhi mahin.ahmadipishkuhi@gmail.com 100319475328460018051 100319475328460018051 No Pars Advanced And Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Science, Tehran, Iran. Nasrin Barzegari El.naz66@yahoo.com 100319475328460018052 100319475328460018052 No Baharloo Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran