en Neurology Neurology Original Article Original Article <span style="font-size: 14px;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background</em></strong><em>:</em></span> To determine whether it is possible to predict intravenous thrombolytic therapy (IVT) outcome after 3 months in acute ischemic stroke patients who are candidate to receive recombinant tissue plasminogen activator (rt-PA), before rt-PA administration based on their risk factors and some available laboratory results.<br> <span style="color: rgb(0, 0, 255);"><strong><em>Methods</em></strong><em>:</em></span> We enrolled 118 ischemic stroke patients who were treated with standard dose of Alteplase in our hospital. Baseline characteristics, door-to-needle time (DTN), onset-to-treatment time (OTT), the National Institute Health Stroke Scale (NIHSS), systolic and diastolic blood pressure on admission, history of diabetes, hypertension, dyslipidemia, coronary artery disease (CAD), previous ischemic stroke, atrial fibrillation (AF), laboratory results were retrospectively collected. The modified Rankin Scale (mRS) was recorded after 3 months of admission and patients were divided into good (mRS&pound; 2) and poor (mRS>2) outcome groups. Chi-square test and t-test were used for categorical and continuous variables, respectively. Predictors for outcome after 3 months were studied by multivariable logistic regression.<br> <span style="color: rgb(0, 0, 255);"><strong><em>Results</em></strong><em>:</em> </span>Good outcome was seen in 60 (51%) patients and poor outcome was seen in 58 (49%) patients. Significant predictors for outcome at 3 months according to multivariable regression analysis were NIHSS score (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.498-0.750; p<0.001), SBP (OR, 0.95; 95% CI, 0.925-0.991; P=0.01), AF (OR, 0.09; 95% CI, 0.013- 0.708; P=0.02), CAD (OR, 17.08; 95% CI, 0.013-0.708; p=0.003).<br> <span style="color: rgb(0, 0, 255);"><strong><em>Conclusion</em></strong><em>:</em></span> Higher NIHSS score, higher SBP on admission, AF and history of CAD could be the independent predictors of outcome after IVT in acute ischemic stroke patients.</span></span> ischemic stroke, thrombolytic therapy, rt-PA 424 430 http://caspjim.com/browse.php?a_code=A-10-1210-1&slc_lang=en&sid=1 Masoud Mehrpour Dr.MasoudMehrpour@gmail.com 100319475328460018840 100319475328460018840 No Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, (IUMS), Tehran, Iran Motahareh Afrakhteh mt_afrakhte@yahoo.com 100319475328460018841 100319475328460018841 No Department of Neurology, Firoozgar Hospital Iran, University of Medical Sciences (IUMS) Tehran, Iran Seyedeh Fahimeh Shojaei shojaee.fahimeh@yahoo.com 100319475328460018842 100319475328460018842 No Firoozgar Clinical Research and Development Center(FCRDC), Iran University of Medical Sciences(IUMS) , Tehran,Iran Ahmad Sohrabi ahmadsohrabi1368@gmail.com 100319475328460018843 100319475328460018843 No Infectious disease research center, Golestan University of Medical Sciences, Gorgan, Iran Rezan Ashayeri re.Ashayeri@gmail.com 100319475328460018844 100319475328460018844 No Department of Neurology, Firoozgar Hospital Iran, University of Medical Sciences (IUMS) Tehran, Iran Sara Esmaeili sara.es64@gmail.com 100319475328460018845 100319475328460018845 No Department of Neurology, Firoozgar Hospital Iran, University of Medical Sciences (IUMS) Tehran, Iran Maryam Bahadori Maryam.bahadori.1987@gmail.com 100319475328460018846 100319475328460018846 Yes Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences(IUMS), Tehran, Iran