en Nephrology Nephrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background</em></strong><em>:</em></span> Parkinson&rsquo;s disease (PD) is one of the most common neurodegenerative diseases (ND). Studies have demonstrated that biochemical markers have an association with PD. We aimed to investigate an association of biochemical markers including calcium, vitamin D, alkaline phosphatase (ALP), parathormone (PTH), and phosphorous with PD.<br> <span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em></span> This study was conducted on 139 PD patients and 100 healthy individuals. Serum levels of calcium, phosphorous, ALP, PTH and vitamin D were evaluated. Furthermore, student&rsquo;s t-test and logistic regression models were used by SPSS.<br> <span style="color:#0000FF;"><strong><em>Results</em></strong><em>:</em> </span>The mean levels of calcium (9.4&plusmn;0.7 and 9.0&plusmn;0.8 ) and vitamin D (29.7&plusmn;22.1 and 25.8&plusmn;23.7) were higher in PD patients as compared with healthy controls, which only status of calcium being significantly different in the two groups (P<0.001). Levels of ALP (202.4&plusmn;96.7 and 242.9&plusmn;142.4) and phosphorous (3.6&plusmn;0.6 and 4.22&plusmn;1.1) were significantly different comparing PD patients with healthy subjects (P<0.01, P<0.001, respectively). ALP and phosphorous were significantly different in the two groups (OR=0.996, [CI 95%, 0.994-0.999], P <0.001, OR= 0.475, [CI 95%, 0.325-0.694], P<0.001, respectively). Furthermore, increased levels of calcium resulted in an elevated risk of PD (OR= 2.175, [CI 95% 1.377-3.435], P <0.001).<br> <span style="color:#0000FF;"><strong><em>Conclusion</em></strong><em>:</em></span> Results show that mean levels of calcium are higher in PD patients relative to healthy controls. Thereby, higher levels of calcium may be associated with PD.</span></span> Parkinson’s disease, Calcium, Biochemical markers 28 33 http://caspjim.com/browse.php?a_code=A-10-1307-1&slc_lang=en&sid=1 Sadra Samavarchi Tehrani tehranisadra94@gmail.com 100319475328460019898 100319475328460019898 No Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Mohammad Sarfi m-sarfi@razi.tums.ac.ir 100319475328460019899 100319475328460019899 No Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran Tooba Yousefi tooba.usefi@gmail.com 100319475328460019900 100319475328460019900 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Alijan Ahmadi Ahangar ahmadiahangaralijan@yahoo.com 100319475328460019901 100319475328460019901 No Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Hemmat Gholinia h_gholinia@yahoo.com 100319475328460019902 100319475328460019902 No Health Research Institute, Babol University of Medical Sciences, Babol, Iran Reza Mohseni Ahangar rezamohseni1234@yahoo.com 100319475328460019903 100319475328460019903 No Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Mahmoud Maniati maniatim@yahoo.com 100319475328460019904 100319475328460019904 No English Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Payam Saadat Sepanta1968@yahoo.com 100319475328460019905 100319475328460019905 Yes Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran