en Dentistry Dentistry Original Article Original Article <p style="margin: 0px; text-align: justify; line-height: 200%;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><em><strong>Background: </strong></em></span>The decisive etiology of Oral squamous cell carcinoma (OSCC) &nbsp;is still ambiguous, but we recognize the contribution of genetic aberration and environmental agent due to OSCC initiation. In the current study, we elucidate the potential impact of EGFR gene polymorphisms in the risk of OSCC in the southeast of Iran.<br> <span style="color:#0000ff;"><em><strong>Methods:</strong></em></span> Forty-eight OSCC patients along with 100 normal volunteers were included. Three polymorphisms of EGFR gene (rs2227983, rs2293347 and rs2227984) were genotype by Tetra-ARMS PCR. Data analyzed with chi-square test and P-value < 0.05 was considered significant.<br> <span style="color:#0000ff;"><em><strong>Results:</strong></em></span> In rs2227983, the frequency of AG and GG genotypes were 62.5%, 37.5% in cases and 42%, 57% in the control group (P = 0.02, OR = 2.3) and also A allele frequency was <span dir="RTL">31.3</span>% in case and 22% in the control (P= 0.08, OR= 0.62). AG + AA genotype frequency was 62.5% and 43% in case and control, respectively (P = 0.03, OR = 2.2). In rs2227984 and rs2293347 no statistical differences showed in the distribution of genotypes between the case and control group, also the majority of the OSCC has belonged to the grade I (43.8%).<br> <span style="color:#0000ff;"><em><strong>Conclusions:</strong></em></span> The present investigation indicated that rs2227983 polymorphism may contribute to OSCC susceptibility in the southeast population of Iran. Although with the inconsistent interpretation mentioned due to the various geographical residency and different populations, more study of major population suggested being performed our finding validation.</span></span></p> oral squamous cell carcinoma, epidermal growth factor receptor, polymorphisms 391 397 http://caspjim.com/browse.php?a_code=A-10-1325-1&slc_lang=en&sid=1 Shirin Saravani shirin.saravani@gmail.com 100319475328460024919 100319475328460024919 No Department of Oral & Maxillofacial Pathology, Faculty of dentistry, Zahedan University of Medical Sciences, Zahedan, Iran Negin Parsamanesh neginparsa.684@gmail.com 100319475328460024920 100319475328460024920 No Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran Ebrahim Miri-Moghaddam moghaddam4@yahoo.com 100319475328460024921 100319475328460024921 Yes Cardiovascular Disease Research Center & Department of Molecular Medicine, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran