en Infectious Diseases Infectious Diseases case report case report <span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background</em></strong><em>:</em></span><span style="color:#000000;">&nbsp;Mucormycosis&nbsp;is an uncommon fungal infection caused by the members of the order Mucorales. In susceptible patients, mucormycosis can infect any tissue or organ, and wit</span>hout suitable treatment (i.e., debridement and antifungal therapy), this infection can be fatal. Our patient was a woman with lymphoma and cerebral mucormycosis who was treated with antifungals and without any neurosurgical debridement.<br> <span style="color:#0000FF;"><strong><em>Case Presentation:</em></strong></span> Herein, we present the case of a 35-year-old woman with diagnosis of B-cell lymphoma and rhino-orbito-cerebral mucormycosis (ROCM). She was a candidate for enucleation of the left eye, orbital decompression, and sinocerebral debridement. Nevertheless, the patient refused eye enucleation and craniotomy. Finally, she was treated with a combination of antifungals and sinus debridement without eye enucleation and craniotomy.<br> <span style="color:#0000FF;"><strong><em>Conclusion:</em></strong></span> Endoscopic debridement, along with a combination of liposomal amphotericin B (LAMB) and posaconazole, may be a suitable therapeutic option for patients with ROCM, who are not eligible candidates for extensive surgery or craniotomy.</span></span> Mucormycosis, Invasive fungal infection, Combination drug therapies, Liposomal amphotericin B, Posaconazole 227 230 http://caspjim.com/browse.php?a_code=A-10-1178-3&slc_lang=en&sid=1 Mohammad Reza Salehi salehi.mohamad3@gmail.com 100319475328460021804 100319475328460021804 No Imam Khomeini Complex Hospital, Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran Farhad Shahi fshahi@yahoo.com 100319475328460021805 100319475328460021805 No Department of Adult Hematology and Oncology, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran Fatema Sadaat Rizvi fateme.sadaat1@gmail.com 100319475328460021806 100319475328460021806 No School of Medicine, Tehran University of Medical Science, Tehran, Iran Sara Ghaderkhani sghaderkhani@gmail.com 100319475328460021807 100319475328460021807 No Imam Khomeini Complex Hospital, Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran Hamed Zainaldain Ahmad.23088@gmail.com 100319475328460021808 100319475328460021808 No School of Medicine, Tehran University of Medical Science, Tehran, Iran Sadegh Khodavaysi sadegh_7392008@yahoo.com 100319475328460021809 100319475328460021809 No Division of molecular biology, Department of medical mycology and parasitology, School of public health, Tehran university of medical science, Tehran, Iran Saeed Reza Jamali-Moghaddam saeedjamali99@yahoo.com 100319475328460021810 100319475328460021810 No Ziaeian Hospital, Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran Seyed Ali Dehghan Manshadi sealdema@yahoo.com 100319475328460021811 100319475328460021811 Yes Imam Khomeini Complex Hospital, Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran Omid Rezahosseini omidrezahosseini@yahoo.com 100319475328460021812 100319475328460021812 No Imam Khomeini Complex Hospital, Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran