en Endocrinology Endocrinology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong><span style="color:#0000ff;"><em>Background:</em></span>&nbsp;</strong>Cardio-metabolic syndrome indicates the clustering of several risk factors. The aims of this study were to identify the subgroups of the Iranian children and adolescents on the basis of the components of the cardio-metabolic syndrome and assess the role of demographic characteristics, socioeconomic status and life style related behaviors on the membership of participants in each latent class.&nbsp;<br> <strong><span style="color:#0000ff;"><em>Methods:</em></span> </strong>&nbsp;This cross sectional study was performed on 3730 Iranian students in 2015 using stratified cluster. All students in each class completed anonymous and structured questionnaires. Abdominal obesity, high triglyceride (TG), low high-density lipoprotein (HDL), high blood pressure (BP), high fasting blood sugar (FBS), high low-density lipoprotein (LDL), high cholesterol and obesity were used for assessing pattern of cardio metabolic risk as a latent variable. Data analysis was performed using PROC LCA in SAS software.<br> <strong><span style="color:#0000ff;"><em>Results:</em></span> </strong>Four latent classes were identified in this study; namely 1) healthy (59.6%), 2) low risk (20.4%), 3) moderate risk (13.7%) and 4) high risk (6.4%). Being girl (OR=0.59, 95% CI: 0.46-0.74), living in rural area (OR=0.45, 95% CI;0.33-0.60), high screen time (OR=1.56, 95% CI:1.09-2.24), and parental obesity (OR=1.52, 95% CI: 1.18-1.95) were associated with moderate risk class. Only living in rural area (OR=0.71, 95% CI; 0.51-0.99) was associated with high risk class.<br> <span style="color:#0000ff;"><em><strong>Conclusion:</strong></em></span> About 20% of the students are in the moderate risk and high risk classes. &nbsp;Design and implementation of interventions according to risk-based class seems necessary with considering probably risk and protective factors for prevention of complications of cardiometabolic syndrome.</span></span> cardiometabolic, metabolic syndrome, latent class analysis, children and adolescents, Iran 370 376 http://caspjim.com/browse.php?a_code=A-10-1357-1&slc_lang=en&sid=1 Abbas Abbasi-Ghahramanloo abbasi.abbas49@yahoo.com 100319475328460024903 100319475328460024903 No Department of public health, School of Health, Ardabil University of Medical Sciences, Ardabil, Iran Ramin Heshmat rheshmaat@tums.ac.ir 100319475328460024904 100319475328460024904 No Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Amir-masood Rafiemanzelat am_rafiemanzelat@yahoo.com 100319475328460024905 100319475328460024905 No School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Kimia Ghaderi kimia.ghaderi386@gmail.com 100319475328460024906 100319475328460024906 No Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Mohammad Esmaeil Motlagh motlagh@health.gov.ir 100319475328460024907 100319475328460024907 No Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Zeinab Ahadi ahadi.ze@gmail.com 100319475328460024908 100319475328460024908 No Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Gita Shafiee gshafiee.endocrine@gmail.com 100319475328460024909 100319475328460024909 No Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Armita Mahdavi-Gorabi armitamahdavi61@gmail.com 100319475328460024910 100319475328460024910 No Department of Basic and Clinical Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran Mostafa Qorbani mqorbani1379@yahoo.com 100319475328460024911 100319475328460024911 No Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran Roya Kelishadi roya.kelishadi@gmail.com 100319475328460024912 100319475328460024912 Yes Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran