en Cardiology Cardiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0033ff;"><strong><em>Background:</em></strong> </span>Early repolarization (ER) is a common finding of the routine electrocardiogram (ECG). The ER usually considered a benign ECG finding, nevertheless a controversy. This study was conducted to investigate the relationship between early repolarization (ER) and the severity of coronary artery disease in patients with a diagnostic coronary angiography.<br> <span style="color:#0033ff;"><strong><em>Methods:</em></strong></span> This case-control study included ninety patients (45 patients and 45 control groups) with a diagnostic angiography and was conducted in 2015. After obtaining informed consent, patients with angiography for ER were considered as cases and those for other purposes were as controls. Data were analyzed using SPSS software Version 16. A p-value lesser than 0.05 was significant.<br> <span style="color:#0033ff;"><strong><em>Results:</em></strong> </span>The frequency of ER was higher in men (75.6%), and there was a significant relationship between sex and ER (P=0.003). The mean age of the patients in the ER group was lower than that of non-ER patients, but not statistically significant (P=0.1). Abnormal angiography was more prevalent in patients with ER than non-ER patients (59.6% vs. 40.4%). ER morphology showed a significant correlation to abnormal angiography and also stenosis severity (P=0.035).<br> <span style="color:#0033ff;"><strong><em>Conclusion:</em></strong></span> ER was higher in men than in women. There was a significant correlation between the existence of ER morphology and atherosclerosis severity. Screening programs for ER detection may reduce the risk of arrhythmias and prevent related complications.</span></span> Early Repolarization, coronary artery disease, electrocardiogram , angiography 526 532 http://caspjim.com/browse.php?a_code=A-10-1275-4&slc_lang=en&sid=1 Roholla Hemmati roholahemmati@gmail.com 100319475328460032109 100319475328460032109 No Department of Cardiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran Yousef Mohsenzadeh ymohsenzadeh1979@gmail.com 100319475328460032110 100319475328460032110 No Department of Cardiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran Shirvan Salaminia ssalaminia@yums.ac.ir 100319475328460032111 100319475328460032111 Yes Department of Cardiac Surgery, Yasuj University of Medical Science, Yasuj, Iran Fatemeh Sayehmiri fsayehmiri@yahoo.com 100319475328460032112 100319475328460032112 No Student Research Committee, Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran