en Endocrinology Endocrinology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><em><strong>Background:</strong></em></span> Vitamin D is one of the known lipoprotein hormones with metabolic properties. We aimed to determine the serum 25-hydroxy vitamin D concentration in overweight/obese subjects with diabetes mellitus type Ⅱ (DM Ⅱ) in association with systolic and diastolic blood pressure and quality of life compared with healthy participants.<br> <span style="color:#0000ff;"><em><strong>Methods:</strong></em></span> The current case-control study was carried out among 80 overweight/obese subjects with DM Ⅱ, and 77 healthy subjects matched by sex, age and body mass index (BMI). Serum 25-hydroxyvitamin D concentration was measured by ELISA method. In order to examine the quality of life, the Persian version of SF36 questionnaire was used.<br> <span style="color:#0000ff;"><em><strong>Results:</strong></em></span> There was significant difference between diabetic and healthy subjects considering serum 25-hydroxyvitamin D concentration (p=0.012). Serum 25- hydroxyvitamin D concentration was inversely correlated with diastolic blood pressure (p=0.02) and positively associated with physical function (p<0.001), social function (p<0.001) and general health (p<0.001) components of quality of life in diabetic subjects and physical health sub-scale (p=0.004) in all participants.<br> <span style="color:#0000ff;"><em><strong>Conclusion: </strong></em></span>Serum 25-hydroxyvitamin D concentration was significantly lower in diabetic subjects in comparison with healthy controls. There was a significant reverse relationship between serum concentrations of 25-hydroxyvitamin D with diastolic blood pressure and on the other hand, a significant positive relationship with physical function, social function and general health components and physical health subscale of quality of life in participants with DM Ⅱ</span></span> 25-hydroxy vitamin D, diabetes mellitus, Blood pressure, quality of life 267 277 http://caspjim.com/browse.php?a_code=A-10-1385-2&slc_lang=en&sid=1 Naser Aghamohammadzadeh nmzmd@yahoo.com 100319475328460023520 100319475328460023520 No Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Neda Dolatkhah neda_dolatkhah@yahoo.com 100319475328460023521 100319475328460023521 Yes Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran Maryam Hashemian hashemian3@yahoo.com 100319475328460023522 100319475328460023522 No Department of Biology, School of Arts and Sciences, Utica College, Utica, USA Seyed Kazem Shakouri skshakouri@gmail.com 100319475328460023523 100319475328460023523 No Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran Saeed Hasanpour saeed.hasan1397@gmail.com 100319475328460023524 100319475328460023524 No Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran