en Ophtalmology Ophtalmology Original Article Original Article <span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background</em></strong><em>:</em></span> To investigate the possibility that the eradication of <em>H pylori</em> infection is associated with a reduction in the risk of glaucoma.<br> <span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em></span> Sixty-five successive patients with elevated intraocular pressure (IOP) or glaucoma were included in the study. Serum samples from all subjects were analyzed for the presence of <em>H pylori</em>- antibodies using ELISA. Forty patients with positive serologic test were included. Half of the patients enrolled into intervention group and the other half registered as control. Intervention arm was referred to the Gastroenterology Clinic for eradication of <em>H pylori</em> and evaluated for the effect of <em>H pylori</em> regimen eradication on IOP and glaucoma over 2 months of follow-up. The age-matched controls did not receive treatment. Urea breath test was applied to confirm eradication.<br> <span style="color:#0000FF;"><strong><em>Results: </em></strong></span>There was a significant (p=0.005) reduction in IOP after complete eradication in the intervention group.&nbsp; This value was not significant in control patients (p=0.08). The mean IOP before treatment of glaucoma in the control group was 23.60&plusmn;2.37 mmHg and after treatment with anti-glaucoma drugs was 14.25&plusmn;1.48 mmHg on the onset of study, and 13.55&plusmn;2.01 mmHg after follow up. The mean IOP before treatment of glaucoma in the intervention group was 24.55&plusmn;3.6 mmHg and after treatment with anti-glaucoma drugs was 15.15&plusmn;1.8 mmHg, and 14.3&plusmn;1.6 mmHg after the eradication of H pylori with a drug regimen. However, after the treatment of glaucoma in all patients, the overall comparison of mean IOP differences showed no statistical difference (P=0.65).<br> <span style="color:#0000FF;"><strong><em>Conclusion</em></strong><em>:</em> </span><em>H pylori</em> eradication therapy may have a positive effect on the management of glaucoma.</span></span><p style="margin: 0px 0px 13.33px; text-align: justify; line-height: normal; text-justify: inter-ideograph;"></p> Helicobacter Pylori Infection, Open- Angel Glaucoma, Management, Eradication, intraocular pressure 143 149 http://caspjim.com/browse.php?a_code=A-10-1476-1&slc_lang=en&sid=1 Shahram Ala sh204ala@yahoo.com 100319475328460021733 100319475328460021733 No Pharmaceutical Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Iradj Maleki iraj2001@yahoo.com 100319475328460021734 100319475328460021734 No Department of Internal Medicine, Imam Khomeini Hospital, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Ali Sanjari Araghi alisanjari1964@yahoo.com 100319475328460021735 100319475328460021735 No Department of Ophthalmology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Adeleh Sahebnasagh masoomehsahebnasagh@gmail.com 100319475328460021736 100319475328460021736 Yes Clinical Research Center, Department of Internal Medicine, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran Anahita Shahraki ani.pharmacist@yahoo.com 100319475328460021737 100319475328460021737 No Pharmaceutical Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran