en pharmacology pharmacology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><em><span style="color:#0000ff;"><strong>Background:</strong></span></em> The aim of this study was to investigate the effects of <em>Melissa officinalis</em> tea on the total antioxidant capacity of saliva among smokers.<br> <strong><em><span style="color:#0000ff;">Methods:</span></em> </strong>24 smokers were selected by convenience sampling. Demographic information and duration of smoking were recorded at the beginning of study. Two cups of <em>Melissa officinalis</em> tea were given to the participants with specific instruction for 30 days. The unstimulated saliva was collected on first day, 15^th and 30^th days. Then, total antioxidant capacity was measured by a special kit. Statistical analysis was conducted by repeated measure ANOVA test.<br> <em><span style="color:#0000ff;"><strong>Results: </strong></span></em>The mean values of total antioxidant capacity of saliva was significantly higher in days 15 and 30 from the baseline. (p<0.0001, p=0.006). In day 30, the mean value of antioxidant was not significantly different from day 15. (p=0.271).<br> <em><span style="color:#0000ff;"><strong>Conclusion: </strong></span>Melissa officinalis</em> tea consumption increase salivary antioxidants level in smokers.</span></span> Melissa officinalis, Antioxidant, Saliva, Smoking. 437 440 http://caspjim.com/browse.php?a_code=A-10-1541-1&slc_lang=en&sid=1 Sedigheh Bakhtiari bakhtiari_s@yhoo.com 100319475328460024955 100319475328460024955 No Oral and Maxillofacial Medicine, School of Dentistry, Shahid Beheshti University of Medical Science, Tehran, Iran Zahara Yadegari yadegari_Z@yahoo.com 100319475328460024956 100319475328460024956 No Department of Dental Biomaterials,Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran Poriya Ehyaei ehyaei_p@yahoo.com 100319475328460024957 100319475328460024957 No Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran Narges Gholizadeh n.gholizadeh88@gmail.com 100319475328460024958 100319475328460024958 Yes Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical science , Tehran, Iran