en Pathology Pathology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background</em></strong><em>:</em></span> Cutaneous pseudolymphoma can histologically and clinically simulate various types of cutaneous lymphoma. We conducted the current study to evaluate the clinicopathological and immunohistochemical (IHC) aspects of cutaneous pseudolymphoma (PSL).<br> <span style="color:#0000ff;"><strong><em>Methods</em></strong><em>:</em></span> 30 cases of cutaneous PSL were selected from the archives of 2013-2017 in Shahid Faghihi Hospital pathology lab, Shiraz University of Medical Sciences. Available clinical data, histopathological features and IHC findings were statistically analyzed.<br> <span style="color:#0000ff;"><strong><em>Results</em></strong><em>:</em></span> The female: male ratio was 2:1 and the median age was 47&plusmn;14.9 years. The lesions were located on the head and neck 26 (86.7%), trunk 2 (6.7%) and extremities 2 (6.7%). 23 (76.7%) cases had nodular pattern, while 7 (23.3%) showed diffuse pattern. The grenz zone was seen in 24 (80%) cases. Sixteen (53.3%) cases showed top heavy infiltration, 11 (36.7%) showed the same distribution of infiltration at the superficial and deep dermis, often involving the subcutaneous fat and 3(10%) showed bottom heavy infiltration. In IHC, 11(36.6%) cases showed the B cell type, 10 (33.3%) T cell type and 9 (30%) mixed type (B and T cells).<br> <span style="color:#0000ff;"><strong><em>Conclusion</em></strong><em>:</em></span> None of the cases was suspicious for cutaneous lymphoma, applying IHC staining. Gender distribution, and the site of cutaneous lesions were similar to previous studies. The most common histological subtype was nodular, while the B-cell cutaneous pseudolymphoma was slightly more common compared to the T-cell type.</span></span> Cutaneous, Pseudolymphoma, Immunohistochemistry. 283 289 http://caspjim.com/browse.php?a_code=A-10-1602-1&slc_lang=en&sid=1 Fatemeh Sari Aslani sari_aslani_f@yahoo.com 100319475328460029355 100319475328460029355 Yes Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Mozhdeh Sepaskhah sepaskhah_m@yahoo.com 100319475328460029356 100319475328460029356 No Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Akbar Safaei safaeia@sums.ac.ir 100319475328460029357 100319475328460029357 No Department of pathology, Shiraz University of Medical Sciences, Shiraz, Iran Seddigheh Jashounia Hormozi dr.sd.hormozi@gmail.com 100319475328460029358 100319475328460029358 No Department of pathology, Shiraz University of Medical Sciences, Shiraz, Iran