Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1399
2
1
gregorian
2020
5
1
11
3
online
1
fulltext
en
The assessment of function, histopathological changes, and oxidative stress in liver tissue due to ionizing and non-ionizing radiations
Internal
Internal
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><em><strong>Background:</strong></em></span> Compared to past decades, humans are exposed to rapidly increasing levels of radiofrequency electromagnetic radiations (RF-EMF). Despite numerous studies, the biological effects of human exposure to different levels of RF-EMF are not fully understood yet. This study aimed to evaluate the bioeffects of exposure to "900/1800 MHz" and “2.4 GHz" RF-EMFs, and x-rays alone as well as their potential interactions, i.e. inducing simple additive, adaptive, or synergistic effects.<br>
<span style="color:#0000ff;"><em><strong>Methods:</strong></em></span> 120 Wistar rats were randomly divided into ten groups of 12 each. The rats were exposed to RF-EMF, 10 cGy, and 8 Gy x-rays, a combination of these exposures, or only sham-exposed. The levels of liver enzymes were determined in serum samples by an autoanalyzer. Moreover, the histopathological changes, and the levels of malondialdehyde (MDA), nitric oxide, ferric reducing antioxidant power, total thiols, and protein carbonyl (PCO) were measured. <span style="color:#0000ff;"><em><strong>Results:</strong></em></span> Among the markers of liver function, gamma-glutamyltransferase was not associated with irradiation but, aspartate transaminase, alanine transaminase, and alkaline phosphatase showed some levels of association. MDA and PCO levels after 8 Gy irradiation increased, but pre-exposure to RF-EMF could modulate their changes. At the cellular level, the frequency of lobular inflammation was associated with the type of intervention.<br>
<span style="color:#0000ff;"><em><strong>Conclusion:</strong></em></span> The exposure to both ionizing and non-ionizing radiations could alter some liver function tests. A short term pre-exposure to RF-EMF before exposure to an 8 Gy challenging dose of x-rays caused the alterations in oxidative stress markers and liver function tests, which indicate that oxidative stress is possibly involved in the adaptive response.</span></span>
EMF, Ionizing Radiation, Liver, Liver Function Tests, oxidative stress
315
323
http://caspjim.com/browse.php?a_code=A-10-1636-1&slc_lang=en&sid=1
Sajad
Borzoueisileh
sajadborzouei@gmail.com
100319475328460023549
100319475328460023549
No
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Ali
Shabestani Monfared
monfared_ali@yahoo.com
100319475328460023550
100319475328460023550
Yes
Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol Iran
Hossein
Ghorbani
hs.ghorbani@mubabol.ac.ir
100319475328460023551
100319475328460023551
No
Department of Pathology , Babol University of Medical Sciences, Babol, Iran
S. M. J.
Mortazavi
mmortazavi@sums.ac.ir
100319475328460023552
100319475328460023552
No
Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Mohsen
Shafiee
mohsen.shafiee@gmail.com
100319475328460023553
100319475328460023553
No
Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
Amir Hossein
Doustimotlagh
amirhosseindoustimotlagh@gmail.com
100319475328460023554
100319475328460023554
No
Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
Ebrahim
zabihi
e_zabihi@yahoo.com
100319475328460023555
100319475328460023555
No
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Mehdi
Pouramir
pouramir@yahoo.com
100319475328460023556
100319475328460023556
No
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Fatemeh
Niksirat
niksirat.fateme@gmail.com
100319475328460023557
100319475328460023557
No
Department of Medical Physics Radiobiology and Radiation Protection, School of Medicine, Babol University of Medical Sciences, Babol, Iran