en Radiology Radiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background</em></strong><em>:</em> </span>In this research, we aimed to survey the added value of single photon emission computed tomography (SPECT) in comparison with planar whole body bone scan to visualize&nbsp;bone metastatic&nbsp;lesions in patients with&nbsp;breast cancer.<br> <span style="color:#0000ff;"><strong><em>Methods</em></strong><em>:</em></span> A total of 80 patients with breast cancer (invasive ductal carcinoma) were examined with planar whole body bone scan and SPECT imaging using 99mTc-labelled methylene diphosphonate (99mTc-MDP). The patients with abnormal uptakes in SPECT imaging were also investigated with magnetic resonance imaging (MRI).<br> <span style="color:#0000ff;"><strong><em>Results</em></strong><em>:</em></span> Among these 80 patients with normal whole body bone SPECT scan, 19 (23.25%) of them revealed abnormal 99mTc-MDP uptake in skeleton. Furthermore, these 19 patients were subjected to MRI and 3 (3.75%) of them were confirmed with metastatic bone lesion.<br> <span style="color:#0000ff;"><strong><em>Conclusion</em></strong><em>:</em></span> The obtained data suggest that SPECT possess the added diagnostic over planar whole body bone scan.</span></span> 99mTc-MDP, SPECT, whole body bone scan, breast cancer, bone metastasis 290 293 http://caspjim.com/browse.php?a_code=A-10-1649-1&slc_lang=en&sid=1 Seyed Mohammad Abedi mabedi167@yahoo.com 100319475328460029359 100319475328460029359 No 1. Department of Radiology and Nuclear Medicine , Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran Alireza Mardanshahi amardanshahi@yahoo.com 100319475328460029360 100319475328460029360 Yes 1. Department of Radiology and Nuclear Medicine , Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran Reza Zeinali reza.zeinali@gmail.com 100319475328460029361 100319475328460029361 No Department of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran