en Nutrition Review Article Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b> <span lang="EN-IN">Osteoarthritis (OA) is characterized by cartilage and synovial inflammation as well as anomalous lower extremity leading to joint pain, and impairment in lifestyle and epidemic of obesity. This study aimed to use the Jumpstart Nutrition&reg; supplement (JNS) for achieving symmetry of aberrant lower extremity and improving the outcome measures in the management of OA</span>. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN-IN">This week-twelve registry included 108 patients treated with JNS mainly comprised of calcium, phosphorus, magnesium, vitamin-K₂, coenzyme-Q₁₀, vitamin-C, boswellic acids, and curcumin mixed with soy and whey proteins (experimental group) and 72 were treated with symptomatic slow-acting drugs (control group) for chronic OA confirmed with radiological images. The outcome measures (Visual analogue scale, Western Ontario and McMaster Universities Osteoarthritis Index, Knee-injury Osteoarthritis Outcomes Scale, and Body mass index), and anomalous lower extremity included bilateral: knee gaps between biceps femoris-short head and surface of the bed, diameters of muscles at the calf, the thigh, 4cm above and below the patella, angles of straight leg raising, knee- flexion and-extension in supine were evaluated with appropriate protocol at week-0 and at week-12 for both the groups</span>.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN-IN">After week-12, risk ratios of studied lower extremity, and mean &plusmn;standard deviation of all outcome measures were significantly improved (p<0.0001), and Kellgren-Lawrence scale (KLS) was upgraded to &ge;2 in experimental group compared to control</span>.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusions:</span></i></b> <span lang="EN-IN">This registry study indicates that JNS can be used to achieve symmetry of studied lower extremity and to improve the outcome measures safely as an effective management of OA patients confirmed with radiological images correlated with KLS</span>.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; Osteoarthrosis, dietary supplement, abnormal lower extremities, aberrant outcome measures, symptomatic slow-acting drugs 1 27 http://caspjim.com/browse.php?a_code=A-10-1136-4&slc_lang=en&sid=1 Apurba Ganguly apurbaganguly15@gmail.com 100319475328460046211 100319475328460046211 Yes Department of Biochemistry, Techno India University, Salt Lake, Kolkata, India