en Nephrology Nephrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background</em></strong><em>:</em></span> Both clinical and experimental evidence have been published over the past few decades supporting the existence of a close relationship between the elevated levels of serum uric acid with cardiovascular events and acute kidney injury (AKI). This study aimed to determine the effect of serum uric acid levels on the incidence of AKI in acute coronary syndrome (ACS) patients.<br> <span style="color:#0000ff;"><strong><em>Methods</em></strong><em>:</em></span> A retrospective cohort study with a cross sectional design was performed. The research was conducted at Dr. Wahidin Sudirohusodo Hospital from October 2019 to December 2019. Nonrandom sampling was employed in the medical records. All patients who met the inclusion criteria were at > 18 years old and diagnosed with ACS with AKI. The demographic data of age, sex and serum uric acid levels were recorded. The data obtained were analyzed using the SPSS (Statistical Package for Social Sciences).<br> <span style="color:#0000ff;"><strong><em>Results</em></strong><em>:</em> </span>There were 158 subjects of ACS patients with AKI and 135 without AKI. There was a significant correlation between high uric acid levels with the incidence of AKI in ACS (p<0.001). Patients with high serum uric acid levels were 9.5 times at risk of developing AKI compared to those with normal serum uric acid levels.<br> <span style="color:#0000ff;"><strong><em>Conclusion</em></strong><em>:</em></span> High uric acid level is one of the risk factors for AKI in ACS and indicates 9.5 times at risk of developing AKI compared to normal serum uric acid level. Therefore, it is necessary to monitor serum uric acid level and kidney function in ACS patients.</span></span> Acute kidney injury, Acute coronary syndrome, uric acid 323 326 http://caspjim.com/browse.php?a_code=A-10-1714-1&slc_lang=en&sid=1 Erny Puti erny.puti87@gmail.com 100319475328460029387 100319475328460029387 Yes Division of Nephrology, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia Haerani Rasyid haeraniabdurasyid@yahoo.com 100319475328460029388 100319475328460029388 No Division of Nephrology, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia Pendrik Tandean penrikt@yahoo.com 100319475328460029389 100319475328460029389 No Division of Cardiology, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia Himawan Sanusi wawan0404@yahoo.com 100319475328460029390 100319475328460029390 No Division of Endocrine Metabolic and Diabetes, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia Hasyim Kasim hasyimkasim@yahoo.com 100319475328460029391 100319475328460029391 No Division of Nephrology, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia Syakib Bakri syakibbakri@gmail.com 100319475328460029392 100319475328460029392 No Division of Nephrology, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia Makbul Aman andimkb.aman@gmail.com 100319475328460029393 100319475328460029393 No Division of Endocrine Metabolic and Diabetes, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia Arifin Seweng arifinsw@gmail.com 100319475328460029394 100319475328460029394 No Biostatistics Department, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia