en Gastroentrology Gastroentrology case report case report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background</em></strong><em>:</em></span> Majority of the patients affected by Kaposi sarcoma (KS) have human immunodeficiency virus (HIV). Highly active antiretroviral therapy (HAART) lessened the incidence of AIDS (acquired immunodeficiency syndrome)- related KS. Cutaneous signs are the most common, but involving the gastrointestinal (GI) tract is very important and dangerous because of serious complications including perforation and bleeding.<br> <span style="color:#0000ff;"><strong><em>Case Presentation</em></strong><em>:</em></span> This report is a rare case of gastric-KS presenting as melena in a non-AIDS 67-year-old woman. We describe the diagnosis and management of this rare complication.<br> <span style="color:#0000ff;"><strong><em>Conclusion</em></strong><em>:</em> </span>GI-KS is often asymptomatic with different endoscopic appearances, and maybe present without cutaneous lesions. Thus, a high diagnostic suspicion is needed and we should attend these GI complications.</span></span> Kaposi’s sarcoma, Upper gastrointestinal bleeding, Non-AIDS 413 416 http://caspjim.com/browse.php?a_code=A-10-699-1&slc_lang=en&sid=1 Elahe Zanganeh zanganeh.e@gmail.com 100319475328460031193 100319475328460031193 No Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran Seyed Ashkan Hosseini ashkan_ho59@yahoo.com 100319475328460031194 100319475328460031194 No Mashhad University of Medical Sciences, Mashhad, Iran Mehdi Alimadadi alimadadi1360@yahoo.com 100319475328460031195 100319475328460031195 No Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran Mohammadreza Seyyedmajidi mrsmajidi55@yahoo.com 100319475328460031196 100319475328460031196 Yes Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran