Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1399
12
1
gregorian
2021
3
1
12
2
online
1
fulltext
en
Rectal Diclofenac versus High-Dose Rectal Acetaminophen in Children: a randomized clinical trial
Pediatrics
Pediatrics
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0033ff;"><strong><em>Background</em></strong><em>:</em> </span>Fever is the most common complaint among the children admitted to health care centers. The aim of this study was to compare the anti-pyretic effect of diclofenac and high dose acetaminophen suppository in 1 to 6 years old children.<br>
<span style="color:#0033ff;"><strong><em>Methods</em></strong><em>:</em></span> This double-blind clinical trial study was performed on 1-6-year-old children hospitalized in 17th Shahrivar Teaching Hospital, Rasht, Iran. Children were divided into two groups of 45 using a block randomization design. The first group received a high dose of acetaminophen suppository at a dose of 30 mg/kg and the second group received a diclofenac suppository at a dose of 1 mg/kg. The rectal temperature of the patients was measured using a digital thermometer at the time of drug administration, and one and three hours after that.<br>
<span style="color:#0033ff;"><strong><em>Results</em></strong><em>:</em></span> 90 children were studied in two groups of 45 each. Temperature changes in the diclofenac group were significantly greater than the acetaminophen group, so from zero to 3 hours after administering diclofenac, the temperature decreased to 1.76±0.95°C. This reduction was lower in acetaminophen group (1.26±0.49°C, P=0.019).<br>
<span style="color:#0033ff;"><strong><em>Conclusion</em></strong><em>:</em></span> Both acetaminophen and diclofenac suppositories significantly reduced the rectal temperature. However, the effect of rectal diclofenac on reducing temperature is more than rectal acetaminophen.</span></span>
acetaminophen, diclofenac, fever, rectal, suppository
207
215
http://caspjim.com/browse.php?a_code=A-10-1805-1&slc_lang=en&sid=1
Houman
Hashemian
hashemian@gums.ac.ir
100319475328460028189
100319475328460028189
Yes
Pediatric Diseases Research Center (PDRC), Guilan University of Medical Sciences, Rasht, Iran
Marzie
Fallah Khodadoost
marzie.khodadoost@yahoo.com
100319475328460028190
100319475328460028190
No
Pediatric Diseases Research Center (PDRC), Guilan University of Medical Sciences, Rasht, Iran.