en Pulmonology Pulmonology Original Article Original Article <h3></h3> <h3><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0033ff;"><strong><em>Background</em></strong><em>:</em> </span>Determination of modifiable risk factors for treatment and prevention of acute chronic obstructive pulmonary disease (COPD) exacerbation is very crucial. Therefore, the present study determined the role of serum magnesium level in acute COPD exacerbation.<br> <span style="color:#0033ff;"><strong><em>Methods</em></strong><em>:</em></span> This prospective study involved 100 patients with an exacerbation of COPD. Demographic data were collected for all the patients, and serum magnesium (Mg²⁺) levels were determined at two different time intervals. These patients were given standard treatment for COPD. All the patients were followed up after one month and later at three-month intervals for one year.<br> <span style="color:#0033ff;"><strong><em>Results</em></strong><em>:</em></span> Majority (72%) of the patients had serum Mg²⁺<1.7 mg/dL and the odds of hypomagnesemia was 6.54 times more during exacerbations than when they had stable COPD during follow-up. Patients with serum Mg²⁺<1.7 mg/dL had 9.34 times higher risk of an increased number of acute exacerbations. A significant difference (p<0.05) was observed in the mean serum Mg²⁺ levels and number of COPD exacerbations among patients with hypomagnesemia at different stages of COPD.<br> <span style="color:#0033ff;"><strong><em>Conclusion</em></strong><em>:</em></span> Low serum magnesium level during acute exacerbation is correlated with the increased frequency of acute exacerbation in COPD.</span></span></h3> Serum magnesium, Smoking, Pulmonary diseases, Hypomagnesemia, Normomagnesemia 223 227 http://caspjim.com/browse.php?a_code=A-10-1808-1&slc_lang=en&sid=1 Ketan Kshirsagar kims.submissions@gmail.com 100319475328460028692 100319475328460028692 No Department of medicine, Krishna institute of medical sciences, Karad (Maharashtra)-415110, Virendra C Patil doctor1.kims@gmail.com 100319475328460028693 100319475328460028693 Yes Department of medicine, Krishna institute of medical sciences, Karad (Maharashtra)-415110, Email ID-