Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1400
10
1
gregorian
2022
1
1
13
1
online
1
fulltext
en
Placebo-controlled trial of oral amantadine and zolpidem efficacy on the outcome of patients with acute severe traumatic brain injury and diffuse axonal injury
Neurology
Neurology
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background</em></strong><em>:</em></span> A constituent of diffuse axonal injury (DAI) is supposed to be present in about 1/3 of all severe traumatic brain injury (TBI) as specified by pathologic documents. Diffuse axonal injury is categorized by extensive injury to axons in the brain. A rise in the incidences of TBI, and the limited study to verified effect of drugs like amantadine and zolpidem in improving the consciousness levels of patients with acute traumatic brain injury with axonal injury enthused us to initiate this study in the acute TBI patients.<br>
<span style="color:#0000ff;"><strong><em>Methods</em></strong><em>:</em></span> In our randomized, controlled trial involving patients with acute severe TBI, we studied 66 patients in 3 groups. Group 1 (n=22) received oral amantadine, Group 2 (n=22) received oral zolpidem, whereas group 3 (n=22) received placebo, the first 8 days after injury respectively. The primary outcome measures included GCS (Glashow coma scale) through the initial admission, a complete medical history was recorded, and each patient had a meticulous physical and neurological investigation.<br>
<span style="color:#0000ff;"><strong><em>Results</em></strong><em>:</em></span> We found that the administration of amantadine in an acute phase after injury improved the rate of patients GCS and GOS (Glasgow Outcome Scale) compared with zolpidem and placebo groups, but without any significant statistical difference.<br>
<span style="color:#0000ff;"><strong><em>Conclusion</em></strong><em>:</em></span> Our results has emphasized that because amantadine has intense biochemical effects on several ways, it appears to be beneficial in acute period after DAI-associated TBI.</span></span>
Amantadine, Zolpidem, Traumatic Brain Injury, Diffuse axonal injury
113
121
http://caspjim.com/browse.php?a_code=A-10-423-2&slc_lang=en&sid=1
sajad
shafiee
sajad.shafiee@gmail.com
100319475328460033347
100319475328460033347
No
Department of Neurosurgery, Orthopedic Research Center, Mazandaran University of Medical Sciences, sari, Iran
Saeed
Ehteshami
dr_saeed_ehteshami@yahoo.com
100319475328460033348
100319475328460033348
No
Department of Neurosurgery, Orthopedic Research Center, Mazandaran University of Medical Sciences, sari, Iran
Mahmoodd
Moosazadeh
mmoosazadeh1351@gmail.com
100319475328460033349
100319475328460033349
No
Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
Saeed
Aghapour
paper87@yahoo.com
100319475328460033350
100319475328460033350
No
Department of Neurosurgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Kaveh
Haddadi
kavehhaddadi56@gmail.com
100319475328460033351
100319475328460033351
Yes
Department of Neurosurgery, Orthopedic Research Center, Mazandaran University of Medical Sciences, sari, Iran