en Endocrinology Endocrinology case report case report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background</em></strong><em>:</em></span> Idiopathic central diabetes insipidus (DI) is a rare endocrine disorder that results from total or partial deficiency of vasopressin secretion. It is idiopathic when the cause is unknown, but in many cases, is associated with autoimmune disorders.<br> <span style="color:#0000ff;"><strong><em>Case presentation:</em></strong></span> We present the case of a 44-year-old male with vitiligo and a family history of diabetes mellitus and thyroid disease. The patient presented with polydipsia and polyuria greater than 8 L/day. After water deprivation test, the patient was diagnosed with partial central diabetes insipidus. Contrast-enhanced pituitary magnetic resonance imaging showed decreased brightness of the neurohypophysis and normal thickness of the pituitary stalk. Because desmopressin was not initially available, the patient was managed with chlorpropamide, carbamazepine, and hydrochlorothiazide, and afterwards substituted. During his outpatient checkups, he presented many episodes of polyuria, the last after 13 years, with polyuria of up to 15 L associated with weight loss, and abnormal blood glucose levels; anti-GAD 65 and IA-2 antibodies were negative. He was subsequently diagnosed with diabetes mellitus and received metformin and insulin; this latter was suspended in subsequent check-ups due to hypoglycemic episodes.<br> <span style="color:#0000ff;"><strong><em>Conclusion</em></strong><em>:</em> </span>We highlight the importance of treatment and adequate control of these pathologies, since they share similar clinical manifestations, can easily have electrolyte imbalance and represent a challenge for endocrinologists and internists.</span></span> Central diabetes insipidus, diabetes mellitus, water deprivation test, vitiligo 363 367 http://caspjim.com/browse.php?a_code=A-10-1980-1&slc_lang=en&sid=1 Diego Moreno Marreros diegomorenosud@hotmail.com 100319475328460031143 100319475328460031143 Yes Division of Endocrinology, Clínica Stella Maris, Lima, Perú Marcio José Concepción Zavaleta marcio_conc_zav@outlook.es 100319475328460031144 100319475328460031144 No National University of Trujillo, Faculty of Medicine, Trujillo, Perú Eilhart Jorge Garxia Villasante jorgegarciavillasante@gmail.com 100319475328460031145 100319475328460031145 No Division of Endocrinology, Hospital Nacional Daniel Alcides Carrión, Lima, Perú Esteban Alberto Plasencia Dueñas esteban_alberto147@hotmail.com 100319475328460031146 100319475328460031146 No Division of Endocrinology, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Perú Sofia Ildefonso Najarro avril_631@hotmail.com 100319475328460031147 100319475328460031147 No Division of Endocrinology, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Perú José Carrion Rojas gcarrionr.metabolismo@gmail.com 100319475328460031148 100319475328460031148 No Division of Endocrinology, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Perú Carmen Luisa Achahui Acurio carmen.achahui@gmail.com 100319475328460031149 100319475328460031149 No Division of Endocrinology, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Perú