Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1400
10
1
gregorian
2022
1
1
13
1
online
1
fulltext
en
Serum dipeptidyl peptidase-4 activity and progranulin level in polycystic ovary syndrome
Biochimestry
Biochimestry
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background</em></strong><em>:</em></span> Evidence showed that abnormal alteration of adipokines level may perform a key role in polycystic ovary syndrome (PCOS) pathogenesis. Dipeptidyl peptidase-4 (DPP4) and progranulin (PGRN) are two novel adipokines related to insulin resistance (IR). Thus, we aimed to determine the serum DPP4 activity and PGRN level in PCOS patients with and without IR, and non-PCOS women.<br>
<span style="color:#0000ff;"><strong><em>Methods</em></strong><em>:</em> </span>Ninety women were recruited in the present study including 60 PCOS patients (divided into two groups of 30 IR and 30 non-IR) and 30 non-PCOS women. Serum levels of insulin, fasting blood glucose, PGRN, and DPP4 activity were measured, and IR indices were calculated.<br>
<span style="color:#0000ff;"><strong><em>Results</em></strong><em>:</em></span> DPP4 activity was significantly higher in PCOS-IR and PCOS-NIR patients than non-PCOS women (p<0.001, P=0.011, respectively), whereas no significant variation was detected between two groups of PCOS subjects. There was no significant difference in the level of PGRN in the three groups of the present study.<br>
<span style="color:#0000ff;"><strong><em>Conclusion</em></strong><em>:</em></span> The present study suggests that increasing DPP4 activity may be associated with PCOS.</span></span>
Polycystic ovary syndrome, Dipeptidyl peptidase-4, Progranulin, Adipokine, Insulin resistance
70
75
http://caspjim.com/browse.php?a_code=A-10-71-8&slc_lang=en&sid=1
Maryam
Abolghasemi
mry.abolghasemi@gmail.com
100319475328460033319
100319475328460033319
No
Student Research Committee, Babol University of Medical Sciences, Babol, Iran
Soleiman
Mahjoub
smahjoub20@gmail.com
100319475328460033320
100319475328460033320
Yes
Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Islamic Republic of Iran
Sedighe
Esmaeilzadeh
sesmael@yahoo.com
100319475328460033321
100319475328460033321
No
Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Mazandaran, Iran