en pharmacology pharmacology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background</em></strong><em>:</em></span> Increasing prevalence of diabetes and its complications, including cardiovascular problems, increase the cost of health care. With proper planning to change lifestyle, like costs and complications of type 1 diabetes could be diminished. The present study investigated the effect of aerobic and resistance training on blood CRP level of type 1 diabetic patients as a protective marker on cardiovascular cells.<br> <span style="color:#0000ff;"><strong><em>Methods</em></strong><em>:</em></span> In this descriptive cross-sectional study, 32 patients with type 1 diabetes were divided into two groups of aerobic and resistance exercise training. Serum CRP levels were measured in all patients before and after exercise. Data were analyzed using Mann-Whitney, Bootstrap and SPSS tests.<br> <span style="color:#0000ff;"><strong><em>Results</em></strong><em>:</em></span> In this study, for abnormal data, Bootstrap method was used, which created an acceptable confidence interval. And using analysis of variance to control the effect of CRP (interfering) level before and after exercise was not significant (P=0.37).<br> <span style="color:#0000ff;"><strong><em>Conclusion</em></strong><em>:</em></span> Considering the relationship between exercise training with CRP level in type 1 diabetic patients specially in aerobic training group as well as CRP level according to the training program condition, it can be concluded that there is not effective relationship between this biomarker and exercise training in type 1 diabetic patients.</span></span> Type 1 diabetes, CRP protein, aerobic and resistance training 38 43 http://caspjim.com/browse.php?a_code=A-10-2002-1&slc_lang=en&sid=1 Yousef Moghaddasi Kouchaksaraei ymoghaddasi@yahoo.com 100319475328460033296 100319475328460033296 No 1. Department of Sports Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran Farshad Ghazalian cb89125@gmail.com 100319475328460033297 100319475328460033297 No Department of Physical Education and Sports Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Saeid Abediankenari ymoghaddasi@yahoo.com 100319475328460033298 100319475328460033298 Yes Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran Khosro Ebrahim abbasbiology@yahoo.com 100319475328460033299 100319475328460033299 No Department of Exercise Physiology, Shahid Beheshti University, Tehran, Iran Hossein Abednatanzi ymoghaddasi14@gmail.com 100319475328460033300 100319475328460033300 No Department of Physical Education and Sports Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran