en Endocrinology Endocrinology case report case report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Bardet-Biedl syndrome (BBS) is characterized by obesity, cognitive abnormalities, rod-cone dystrophy, skeletal abnormalities, and many other secondary features.<span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Case Presentation:</span></i></b> We describe a 28-year-old man presented with postaxial polydactyly, retinitis pigmentosa, obesity, hypogonadism and learning difficulties. Renal insufficiency in form of acute kidney injury was the presenting feature and this explain the worse outcome. The diagnosis was delayed despite being classic. This delay in diagnosis leads to a lot of complications that worsen the patient&#39;s condition.<b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> The characteristics of BBS should be noted by doctors because an early diagnosis will result in a better outcome. The case was prone to numerous consequences due to the delay in diagnosis, which could have been avoided if an early diagnosis had been established.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; Bardet-Biedl Syndrome, Polydactyly, Retinitis Pigmentosa 805 809 http://caspjim.com/browse.php?a_code=A-10-2008-1&slc_lang=en&sid=1 Michael Edwar michaelfarag@medicine.zu.edu.eg 100319475328460039917 100319475328460039917 Yes Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt Usama Ragab usamaragab@medicine.zu.edu.eg 100319475328460039918 100319475328460039918 No Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt Ahmed Atia Kamel ahmedatia1991.aak@gmail.com 100319475328460039919 100319475328460039919 No Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt