en Obstetrics & Gynicology Obstetrics & Gynicology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background</em></strong><em>:</em> </span>Misoprostol is a myometrial stimulant with uterotonic properties and can be administered rectally, vaginally, or sublingually. Numerous studies have investigated the effect of misoprostol on the prevention and treatment of PPH (postpartum hemorrhage) after vaginal delivery, but its use to control PPH during cesarean section has not been widely studied.<br> <span style="color:#0000ff;"><strong><em>Methods</em></strong><em>:</em> </span>In this clinical trial study, 180 pregnant women who were candidates for cesarean section were included in the study. They were divided into 3 groups of 60 people (sublingual misoprostol group, rectal misoprostol group, control group). In all three groups, the volume of blood lost was recorded in the checklist at the end of surgery. Data were entered into SPSS software and analyzed.<br> <span style="color:#0000ff;"><strong><em>Results</em></strong><em>:</em> </span>The mean bleeding in the control group was 225.4&plusmn;63.9, while it was 137.9&plusmn;33.8&nbsp;&nbsp; and 118.9&plusmn;28.5 in the sublingual misoprostol group and rectal misoprostol group, respectively. We had significantly more bleeding in the control group (p<0.001) compared to the other two groups.<br> <span style="color:#0000ff;"><strong><em>Conclusion</em></strong><em>:</em> </span>These results confirm the positive effect of misoprostol in reducing bleeding and show the superiority of using rectal misoprostol compared to other methods of reducing bleeding during cesarean section<span dir="RTL">.</span></span></span> misoprostol, rectal administration, sublingual administration, cesarean section, bleeding 84 89 http://caspjim.com/browse.php?a_code=A-10-1593-3&slc_lang=en&sid=1 Fatemeh Zahra Bagheri bagheri.z1994@gmail.com 100319475328460033332 100319475328460033332 No Department of Operating Room, Mazandaran University of Medical Sciences, Sari, Iran Mahboobeh Azadehrah dr.azadehrah@gmail.com 100319475328460033333 100319475328460033333 No Department of Gynecologist and Laparoscopy Fellowship, Golestan University of Medical Sciences, Gorgan, Iran Bizhan Shabankhani Shabankhani@yahoo.com 100319475328460033334 100319475328460033334 No Department of Biostatistics, School of Health, Mazandaran University of Medical Sciences, Sari, Iran Hooshang Akbari bagheri.z1994@gmail.com 100319475328460033335 100319475328460033335 Yes Mazandaran University of Medical Sciences, Sari, Iran Ebrahim Nasiri Ferami pouladkhay.fatemeh@gmail.com 100319475328460033336 100319475328460033336 No Department of Anesthesiology, School of Allied Medical Sciences, Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran university of Medical Sciences, Sari, Iran