en Endocrinology Endocrinology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background:</em></strong></span> Depression as a frequent comorbidity in patients with diabetes requires serious attention, as failure to early detect and treat it can adversely affect the patients&#39; complications<strong>. </strong>This study was performed to assess the prevalence of depression and quality of life in these patients.<br> <span style="color:#0000ff;"><em><strong>Methods:</strong></em></span> This cross-sectional study was carried-out on adult patients with type 2 diabetes mellitus referred to the endocrinology hospital clinics affiliated to Babol University of Medical Sciences, Babol, Iran, during 2018-2019. The presence and severity of depressive symptoms in patients have been assessed by Beck Depression Inventory-II; and the quality of life was measured by SF-36 questionnaire.<br> <strong><em><span style="color:#0000ff;">Results:</span></em></strong> Totally, 400 patients with type 2 diabetes mellitus (300 females and 100 males) with mean age of 55.36&plusmn;11.56 years were recruited. One hundred and thirty (32.5%) had depressive symptoms. Of the patients with depression, 115 (28.8%) had mild and 15 (3.8%) had moderate depression. After entering different variables in logistic regression analysis, gender (P=0.036) and ophthalmic complications (P=0.011) showed a significant association with depressive symptoms. The patients with depression had a worse quality of life compared to those who had not depressive symptoms. Quality of life score in patients with depression was significantly lower than patients without depression (p<0.0001).<br> <span style="color:#0000ff;"><strong><em>Conclusions:</em></strong></span> Nearly one third of the patients with type II diabetes mellitus might have depression. Diabetic patients with depression have a worse quality of life compared to those who have not depression symptoms.</span></span> Diabetes Mellitus, Depression, Quality of Life 335 342 http://caspjim.com/browse.php?a_code=A-10-113-3&slc_lang=en&sid=1 Mohammad Ali Bayani bayanima49@yahoo.com 100319475328460036495 100319475328460036495 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences Nava Shakiba navashakiba7@gmail.com 100319475328460036496 100319475328460036496 No Ayatollah Rouhani Hospital, School of Medicine, Babol University of Medical Sciences, Babol, Iran Ali Bijani alibijani@yahoo.com 100319475328460036497 100319475328460036497 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences Sussan Moudi sussan.mouodi@gmail.com 100319475328460036498 100319475328460036498 Yes Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences