en Obstetrics & Gynicology Obstetrics & Gynicology Short Communication Short Communication Background: Bilateral salpingo-oophorectomy in women may lead to metabolic consequences in patients. This study was performed to determine the glucose tolerance and lipid profile after menopause resulting from bilateral salpingo-oophorectomy. Methods: From September 2011 to March 2013, 31 women participants aged 46-52 years who underwent hysterectomy and bilateral salpingo-oophorectomy for benign reasons were recruited. An oral glucose tolerance test (OGTT), triglyceride (TG), total cholesterol, low density lipoproteis (LDL), high density lipoprotein (HDL) was performed before and 6 months after surgery. Fasting insulin and 2-hour insulin levels, fasting insulin / glucose indexes and homeostasis model assessment HOMA indexes were also measured. Results: The mean age of the patients was 48.6±2.9 years.The mean 2-h glucose level in OGTT changed from 26.7 before surgery to 111.1 (P=0.030). The mean level of lipid profile before and after surgery for TG was 132.3 versus 181.2 (P=0.005), total cholesterol 177.4 versus 206.7 (P=0.0001) and LDL 98.4 versus 115.3 (P=0.003). The other variables showed no significant difference. Conclusion: The results indicate that lipid profile changes like increase of TG, total cholesterol and LDL should be considered before removing the ovary during hysterectomy in premenopausal women. Salpingo-oophorectomy, Menopause, Glucose tolerance, Lipid profile 114 117 http://caspjim.com/browse.php?a_code=A-10-62-179&slc_lang=en&sid=1 Shahla Yazdani 100319475328460015375 100319475328460015375 No Fatemeh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences , Babol, Iran Majid Sharbatdaran 100319475328460015376 100319475328460015376 No Department of Pathology , babol University of Medical Sciences, babol , Iran. Mohammad Abedi Samakoosh 100319475328460015377 100319475328460015377 No Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Zinatossadat Bouzari 100319475328460015378 100319475328460015378 Yes Department of Gynacology, Babol University of Medical Sciences, Babol, Iran Zahra Masoudi 100319475328460015379 100319475328460015379 No . Babol University of Medical Sciences, Babol, Iran