en Cardiology Cardiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Coronary artery disease (CAD) is a cardiovascular disease which is related to mortality and morbidity among the Indians predominantly in the older age group. But, recently CAD has been found more often in young population. Hence, our study aims to observe the outcomes based on various categories of high density lipoprotein (HDL) cholesterol levels estimated during admission at the hospital and correlate the levels of HDL cholesterol with severity of CAD as measured by Gensini score.<span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> A cross-sectional study was conducted in 151 young patients (18-45 years) who were admitted at the hospital with newly diagnosed acute coronary syndrome (ACS). Tests such as electrocardiogram, cardiac enzyme assay, hematologic and biochemical tests including fasting lipid profile levels were taken into account.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> There was an inverse relation observed between the number of vessels involvedand HDL cholesterol levels. Those with lower levels of HDL cholesterol were more vulnerable to multi-vessel CAD. However, no association was observed between HDL cholesterol and severity of CAD as measured by Gensini score.<b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> In young patients with acute coronary syndrome and diminished HDL cholesterol levels had a greater number of vessels involved when compared with elevated HDL cholesterol levels group. However, low HDL cholesterol levels had no association with severity of CAD as measured by Gensini score. No statistically significant association was noticed between levels of HDL cholesterol and in hospital mortality /morbidity.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; Acute coronary syndrome, coronary artery disease, HDL cholesterol, myocardial infarction, Gensini score 675 680 http://caspjim.com/browse.php?a_code=A-10-2096-1&slc_lang=en&sid=1 Arpita Chakraborty arpita.chakraborty2013@gmail.com 100319475328460039785 100319475328460039785 No Department of General Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India CH Sai kumar saikumarchitikeshwarapu1989@gmail.com 100319475328460039786 100319475328460039786 No Department of General Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India Mukhyaprana Prabhu mm.prabhu@manipal.edu 100319475328460039787 100319475328460039787 No Department of General Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India Weena Stanley weena.stanley@manipal.edu 100319475328460039788 100319475328460039788 Yes Department of General Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India Ranjan Shetty ranjanshettyk@yahoo.com 100319475328460039789 100319475328460039789 No Department of Cardiology, Manipal Hospitals, Bangalore-560017, Karnataka, India